进展期消化道恶性肿瘤腹腔热灌注化疗的疗效观察

Curative Effect of Intraperitoneal Hyperthermic Perfusion Chemotherapy for Digestive Tract Cancer at Progressive Stage

目的观察进展期消化道恶性肿瘤腹腔热灌注化疗的疗效和安全性。方法选择我院进展期胃肠道肿瘤患者102例,随机分为两组各51例。对照组采用常规静脉化疗,观察组在静脉化疗的同时联合腹腔热灌注化疗。结果两组的1年生存率无统计学差异(P>0.05);观察组的2、3年生存率均显著高于对照组(P<0.05),3年腹腔内复发率显著低于对照组(P<0.05)。两组的化疗毒副反应以及术后并发症发生率比较,差异均无统计学意义(P>0.05)。结论腹腔热灌注化疗可提高进展期消化道恶性肿瘤的疗效,降低腹腔复发率,而且不增加不良反应,是一项安全有效的治疗措施。

Objective To observe the curative effect and safety of intraperitoneal hyperthermic perfusion chemotherapy for digestive tract cancer at progressive stage. Methods 102 patients with digestive tract cancer at progressive stage were randomly divided into the control group and observation group equally. Both groups were given regular intravenous chemotherapy, while the observation group was given intraperitoneal hyperthermic perfusion chemotherapy additionally. Results No statistical difference was found between two groups in the 1-year survival rate （P〉0.05）; The 2-year survival rate and 3-year survival rate of observation group were significantly higher than those of control group, and the intraperitoneal recurrence rate within 3 years was significantly lower than that of control group （P 〈0.05）. The incidences of adverse reactions of chemotherapy and postoperative complications showed no statistically significant difference between two groups （P 〉0.05）. Conclusions Intraperitoneal hyperthermic perfusion chemotherapy can improve the curative effect of digestive tract cancer at progressive stage and reduce the intraperitoneal recurrence rate, and does not increase the adverse reaction meanwhile.