氧气雾化吸入与含漱防治放射性口腔及口咽黏膜炎的效果比较

Comparison on the Preventive Effectiveness Between Oxygen Atomization Inhalation and Gargle on Radiotherapy Induced Oral and Oropharynx Mucositis

目的观察比较氧气雾化吸入与含漱防治放射性口腔及口咽黏膜炎的效果。方法选择60例鼻咽癌放射治疗患者,随机分为两组各30例,观察组采用氧气雾化吸入法,对照组采用含漱法,观察比较两组患者的治疗情况、放射性口腔及口咽黏膜炎的发生及恢复情况。结果观察组出现Ⅰ、Ⅱ级放射性口腔及口咽黏膜炎的时间明显晚于对照组(P<0.05),两组出现Ⅲ级放射性口腔及口咽黏膜炎的时间无明显差异(P>0.05)。观察组以轻度放射反应(包括Ⅰ、Ⅱ级)为主,对照组以重度放射反应(包括Ⅲ、Ⅳ级)为主,差异有统计学意义(P<0.05)。两组从开始放疗到恢复的时间差异无统计学意义(P>0.05),观察组从放疗结束到恢复的时间短于对照组(P<0.05)。结论氧气雾化吸入防治放射性口腔及口咽黏膜炎的效果优于含漱法。

Objective To observe and compare the effectiveness between oxygen atomization inhalation and gargle for prevention of radiotherapy induced oral and oropharynx mucositis. Methods Sixty cases of nasopharyngeal cancer patients treated with radiotherapy were randomly divided into two groups equally. The observation group was given oxygen atomization inhalation, while the control group was given gargle. The therapeutic condition, the incidence and recovery of radiotherapy induced oral and oropharynx mucositis were compared. Results The occurrence time of grade Ⅰ and gradeⅡ radiotherapy induced oral and oropharynx mucositis of observation group were significantly shorter than those of control group （P 〈0.05）, while no statistical difference was found between two groups in the occurrence time of grade m （P〉0.05）. The radiation reaction of observation group mainly distributed in grade Ⅰ and grade Ⅱ, while the radiation reaction of control group mainly distributed in grade m and grade IV, with statistical difference between two groups （P〈0.05）. No statistical difference was found between two groups in the duration from the start of radiotherapy to recovery （P〉0.05）, while the duration from the end of radiotherapy to recovery of observation group was significantly shorter than that of control group （P 〈0.05）. Conclusions Oxygen atomization inhalation has better efficacy than gargle for prevention of radiotherapy induced oral and oropharynx mucositis.