脑梗死出血转化后继续阿司匹林抗血小板聚集治疗的效果

Effect of Continuous Aspirin Antiplatelet Aggregation Treatment After Cerebral Infarction Hemorrhage Transformation

目的探讨脑梗死出血转化后继续服用阿司匹林临床抗血小板聚集的效果。方法选取我院2013年1月至2015年12月期间120例急性脑梗死入院治疗出现出血症状的患者,按双盲法随机分为实验组60例、对照组60例。在给予相应对症治疗的同时,实验组继续使用阿司匹林,对照组停止服用抗血小板聚集药物并在出血稳定后继续启用。结果治疗后,实验组较对照组纤维蛋白水平指标恢复好(P<0.05),经头颅CT检查显示两组的脑出血量均未见明显增加(P>0.05)。治疗前和治疗3个月后,两组神经损伤程度比较无统计学差异(P>0.05);治疗1个月后,实验组的神经损伤程度评分显著低于对照组(P<0.05)。结论对脑梗死出血转化患者,临床发现出血后继续使用阿司匹林抗血小板治疗,有利于神经功能恢复和血液流变学指标恢复。

Objective To explore the effect of continuous aspirin antiplatelet aggregation treatment after cerebral infarction hemorrhage transformation. Methods 120 cases ＆patients with cerebral infarction hemorrhage transformation in our hospital from January 2013 to December 2015 were selected and randomly divided into two groups equally. All cases were given symptomatic treatment; in addition, the experimental group received aspirin continuously, while the control group stopped using aspirin until the hemorrhage stopped. Results The recovery of fibrin level of experimental group was significantly better than that of control group （P 〈0.05）. CT showed that cerebral hemorrhage volume of both groups had no obvious increase （P〉0.05）. Before treatment and 3 months after treatment, no statistical difference was found between two groups in the degree of nerve injury （P 〉0.05）; one month after treatment, the score of nerve injury of experimental group was significantly lower than that of control group （P 〈0.05）. Conclusions For patients with cerebral infarction hemorrhage transformation, continuous aspirin antiplatelet aggregation treatment is beneficial to the recovery of neurological function and the recovery of blood theology index.