小剂量阿司匹林联合硫酸镁对妊娠期高血压产妇妊娠结局的影响

Effect of Low-Dose Aspirin Combined with Magnesium Sulfate on Gestational Outcomes of Hypertensive Disorder Complicating Pregnancy

目的探讨小剂量阿司匹林联合硫酸镁对妊娠期高血压产妇妊娠结局的影响。方法选取2012年10月至2015年10月我院收治的妊娠高血压孕妇332例．随机分为两组各166例。在常规生活指导基础上，对照组给予硫酸镁治疗，治疗组在对照组的基础上加用阿司匹林治疗。观察两组患者治疗前后的血压变化情况、剖宫产率、妊娠结局。结果经治疗后，治疗组的收缩压、舒张压显著低于对照组（P〈0．05）。治疗组的剖宫产率（42．17％）显著低于对照组（83．13％），差异有统计学意义（P〈0．05）。治疗组的早产、宫内窘迫、产后出血发生率均低于对照组，差异有统计学意义（P〈0．05）。两组的新生儿窒息及羊水Ⅱ°～Ⅲ°混浊发生率比较差异无统计学意义（P〉0．05）。结论小剂量阿司匹林联合硫酸镁能够显著降低妊娠期高血压孕妇的血压、剖宫产率，显著改善妊娠结局，值得临床推广应用。

Objective To investigate the effect of low-dose aspirin combined with magnesium sulfate on gestational outcomes of hypertensive disorder complicating pregnancy. Methods 332 cases of hypertensive disorder complicating pregnancy admitted to our hospital from October 2012 to October 2015 were selected and randomly divided into two groups, with 166 cases in each group. On the basis of regular life guidance, the control group was treated with magnesium sulfate, while the treatment group was treated with low-dose aspirin combined with magnesium sulfate. The blood pressures before and after treatment, cesarean section rate and pregnancy outcome were observed. Results After treatment, the blood pressures of treatment group were significantly lower than those of control group （P 〈0.05）. The cesarean section rate of treatment group was 42.17%, significantly lower than 83.13% of control group （P〈0.05）. The incidences of premature delivery, intrauterine distress and postpartum hemorrhage of treatment group were significantly lower than those of control group （P〈0.05）. No statistical difference was found between two groups in the incidence of neonatal asphyxia and incidence of Ⅱ°～Ⅲ°degree amniotic fluid turbidity （P 〉0.05）. Conclusions Low-dose aspirin combined with magnesium sulfate for the treatment of hypertensive disorder complicating pregnancy can significantly lower the maternal blood pressure and cesarean section rate, and improve the gestational outcome, which is worthy of clinical promotion and application.