右丙亚胺联合参麦注射液对蒽环类药物所致心脏毒性的保护作用观察

Observation on Protective Effect of Dexrazoxane Combined with Shenmai Injection on Cardiac Toxicity Induced by Anthracyclines Drugs

目的探讨右丙亚胺联合参麦注射液对蒽环类药物所致心脏毒性的保护作用。方法选取我院2015年10月至2016年2月间收治的96例癌症患者作为研究对象,均采用蒽环类药物进行治疗,随机分成三组各32例:右丙亚胺组、参麦组、右丙亚胺联合参麦组(联合组)。观察三组患者的心脏毒性反应发生率。结果治疗后,联合组的房室早搏、心室早搏、房室传导阻滞发生率均显著低于其他两组,差异有统计学意义(P<0.05)。联合组的左心室射血分数显著高于其他两组,CK-MB浓度显著低于其他两组,差异均有统计学意义(P<0.05)。结论联合应用右丙亚胺和参麦注射液对使用蒽环类药物所致的心脏毒性有保护作用,能减轻毒副作用对心脏的损伤。

Objective To explore the protective effect ofdexrazoxane combined with Shenmai injection on cardiac toxicity induced by anthracyclines drugs. Methods 96 cases of patients with cancer admitted to our hospital from October 2015 to February 2016 were selected as research objects. All cases were treated with anthracyclines drugs, and randomly divided into three groups： dexrazoxane group, Shenmai injection group and dexrazoxane combined with Shenmai injection group （combined group）. The incidences of cardiac toxicity of three groupswere observed. Results After treatment, the incidences of atrioventricular beats, ventricular premature beats andatrioventricular block of combined group were significantly lower than those of the other two groups （P〈0.05）. After treatment, the left ventricular ejection fraction of combined group was significantly higher than that of the other two groups, and the CK-MB level was significantly lower than that of the other two groups （P〈0.05）. Conclusions The combined application of dexrazoxane and Shenmai injection has protective effect on cardiac toxicity induced by anthracyclines drugs, which can reduce the damage of heart induced by toxic side effect.