中国冠心病患者血栓弹力图与血小板计数和常规凝血检测的相关性分析

Correlation analysis between thromboelastography and routine coagulation tests and platelet count in Chinese coronary artery disease patients

目的分析血栓弹力图(thromboelastography,TEG)与血小板计数和常规凝血检测指标的相关性,为TEG用于中国冠心病患者凝血功能评价提供依据。方法选择2014年7月至2015年3月于本院心内科就诊的冠心病患者为研究对象,应用TEG及常规凝血检测患者凝血功能,分析血小板计数和常规凝血检测指标(凝血酶原时间、国际标准化比值、活化部分凝血活酶时间与纤维蛋白原水平)与TEG参数(凝血反应时间、凝血形成时间、凝固角、最大振幅与血凝块力度强度)的相关性。结果共纳入确诊冠心病患者101例,患者TEG参数中凝血形成时间、最大振幅、血凝块力度强度与血小板计数呈线性相关(P<0.001),最大振幅和血凝块力度强度与患者纤维蛋白原水平呈线性相关(P<0.001)。结论中国冠心病患者TEG参数与血小板计数及纤维蛋白原水平相关,进一步证实了TEG可用于我国冠心病患者凝血情况的临床评价。

Objective To evaluate the correlation between thromboelastography and routine coagulation and platelet tests in Chinese coronary artery disease （CAD） patients. Method Coronary artery disease patients were enrolled from July 2014 to March 2015 in our hospital. Thromboelastography and route blood assays were performed. Correlation between thromboelastography （R, K, a-angle, G, and MA） and routine tests （PT, PT INR, APTT, fibrinogen and platelet count） were analyzed. Result 101 CAD patients were enrolled. The blood coagulation time, maximal amplitude and the intensity of the blood clot were linearly correlated with the platelet count （P 〈 0.01）. The maximum amplitude was linearly related to the intensity of the blood clot and the content offibrinogen in the patients （P 〈 0.01）. Conclusion Preliminary data shows the correlation between TEG and PLT and fibrinogen level in Chinese CAD patients, which validates the use of TEG in management of Chinese CAD patients.