应用基因工程技术增强间充质干细胞移植效果

Genetic engineering techniques to enhance therapeutic effects of mesenchymal stem cells

间充质干细胞(MSCs)在再生医学领域应用前景无限。它取材较容易,无论是天然的还是通过细胞工程诱导获得的均具有多向分化能力。成功的MSCs治疗依赖于有效的细胞输送和移植细胞的长期存活,以便能长久地在目标位点更多地发挥效应。在MSCs移植前应用基因工程技术对其进行修饰可取得这一效果。本文介绍了能提高移植MSCs的迁移能力、防止MSCs衰老和凋亡及提高MSCs存活率的基因工程方法策略。

Mesenchymal stem cells （MSCs） are promising in the field of regenerative medicine due to their relatively easy access and multidifferentiation capabilities, either naturally or induced through cell engineering. Successful MSCs treatment depends on efficient methods of cell delivery and the long-term survival of grafted cells at the target site. The application of genetic engineering technology to modify MSCs before transplantation can accomplish long-term survival. In this review, we describe the genetic engineering strategies to increase the migration ability, decrease senescence and apoptosis and improve the survival of transplantated MSCs.