AIDS宫颈分泌物淋病奈瑟菌、解脲支原体、沙眼衣原体检测及与CD^(4+)T细胞计数和HIV载量的关系

Analysis of HIV/ AIDS Patients Cervical Secretions Gonorrhea,Mycoplasma,Chlamydia Test Results and the Relationship between CD4^+T Cell Count and HIV Load

目的:探讨艾滋病(AIDS)患者宫颈分泌物淋病奈瑟菌(NG)、解脲支原体(UU)、沙眼衣原体(CT)检测结果及与CD^(4+)T细胞计数和HIV载量的关系。方法:检测35例AIDS患者NG、UU、CT、CD^(4+)T细胞计数和HIV载量,并比较NG、UU、CT在不同CD^(4+)T细胞计数(<50/mm^3、50~199/mm^3、200~349/mm^3、≥350/mm^3)及HIV载量(<1000 copy/ml、1000~4999 copy/ml、5000~9999 copy/ml、≥10000 copy/ml)中阳性与阴性患者的构成比。结果:35例AIDS患者的宫颈分泌物NG、UU和CT检测阳性分别为6例(17.1%)、5例(14.3%)和3例(8.6%)。随着CD^(4+)T细胞计数的升高,NG、UU和CT阳性患者的构成比例较阴性患者降低,差异有统计学意义(Z=2.406,Z=2.443,Z=2.252,P<0.05)。随着HIV载量的升高,NG和UU阳性患者的构成比例较阴性患者升高,差异有统计学意义(Z=1.135,Z=2.126,P<0.05);而CT阳性患者的构成比例与阴性患者比较,差异无统计学意义(Z=1.205,P>0.05)。结论:在对低CD^(4+)T细胞计数和高HIV载量的AIDS患者的诊疗中,应当积极检测宫颈分泌物NG、UU和CT,对预防盆腔炎发生有益。

Objective：To explore cervical secretions gonorrhea, mycoplasma, chlamydia test results and the relationship between CD4 ＋T cell count and HIV load in HIV/AIDS patients. On patients with AIDS neisseria gonorrhoeae（ NG）, urea mycoplasma（UU） ,chlamydia trachomatis（CT） positive HIV and CD4＋T cell count and discretion. Methods ：AIDS NG, UU, CT, CD 4 ＋ T cell count and HIV loads were detected in 35 patients with AIDS, and the NG,UU,CT in different CD4＋T cell count（ 〈50 cells/mm3 ,50 -199 cells/ram3 ,200 -349 cells/mm3, 1〉350 cells/mm 3） and HIV loads （ 〈 1000 copy/ml, 1000 - 4999 copy/ml,5000 - 9999 copy/ml, ≥ 10000 copy/ml） in the patients than the composition of the masculine and feminine were compared. Results ：In the 35 cases of AIDS patients,cervical secretions test positive for NG, CT and U U were 6 cases（17. 1% ）,5 cases（14.3% ） and 3 cases（8.6%） ,respectively. With the increase of CD4＋T cell count, NG, UU and CT in patients with positive percentage composition of the negative patients was reduced,the difference was statistically significant（Z = 2. 406, Z=2.443,Z =2. 252;P 〈 0.05）. With the increase of HIV loads, NG percentage composition of the negative and U U positive patients increaseed significantly,the difference was statistically significant（Z = 1. 135, Z=2. 126, P 〈 0.05） ;however,there was no significant difference on the percentage composition between the CT positive patients and negative patients,there was no statistically significant difference（ Z= 1. 205, P 〉0.05）. Conclusions：In the diagnosis and the treatment of AIDS patients with low CD4＋T cell count and high HIV loads,cervical secretions NG, UU and CT should be actively detected to early prevent pelvic infection occurrence.