CMTM7基因在肝细胞癌中的表达及临床意义

Clinical significance of expression of CMTM7 in hepatocellular carcinoma

目的探讨CMTM7基因在肝细胞癌(hepatocellular carcinoma,HCC)及其癌旁正常组织中的表达及其临床意义.方法采用组织芯片技术和免疫组织化学法检测75例HCC及其对应癌旁正常组织中CMTM7基因的表达,分析其与HCC临床病理特征及与患者预后的关系.结果 CMTM7在HCC中的表达(20.00%,15/75)明显低于其癌旁正常组织(81.33%,61/75),组间比较差异有统计学意义(P<0.05).CMTM7表达与HCC患者性别、年龄、吸烟史、饮酒史、乙型肝炎病毒感染、肿瘤家族史、肿瘤数目、病理分级、临床分期、是否合并肝硬化及远处转移等无关,与肿瘤大小、TNM分期和甲胎蛋白水平有相关性(P<0.05).CMTM7阴性组患者的术后生存时间明显低于阳性组,提示CMTM7阴性表达可能与HCC患者的预后有关.结论 CMTM7基因表达下调可能与HCC的发生、发展密切相关.

AIM To detect the expression of CMTM7 in hepatocellular carcinoma（HCC） and to analyze its clinical significance.METHODS Tissue microarray and immunohistochemistry method were used to detect 75 pairs of HCC tissues and tumor-adjacent normal tissues.The relationship of CMTM7 expression with clinical pathological features and overall survival of postoperative patients was analyzed statistically.RESULTS The expression rate of CMTM7 in HCC tissues（20.00%,15/ 75） was significantly lower than that in paired para-carcinoma normal tissues（81.33%,61/ 75;P〈0.05）.The expression of CMTM7 in HCC had no obvious correlation with gender,age,smoking history,drinking history,family history of hepatitis B virus infection or tumor,tumor number,pathological classification,or clinical stage.However,CMTM7 expression had a significant correlation with liver cirrhosis,distant metastasis,tumor size,TNM stage,andα-fetoprotein levels（P〈0.05）.The survival time of postoperative HCC patients in the CMTM7 negative group was obviously lower than that of patients in the CMTM7 positive group,suggesting that CMTM7 expression may be related to the prognosis of HCC patients.CONCLUSION The down-regulated expression of CMTM7 may be closely related with the occurrence and development of HCC.