MUC1 rs4072037基因多态性与胃癌易感性的Meta分析

Association between MUC1 rs4072037 polymorphism and susceptibility to gastric cancer: A meta-analysis based on ten case-control trials

目的探讨MUC1 rs4072037基因多态性与胃癌(gastric cancer,GC)易感性的关系.方法计算机检索PubMed、EMBASE、the Cochrane Library、CBM、CNKI、VIP及万方数据库,收集MUC1 rs4072037基因多态性与GC易感性的病例对照研究.检索时限均为从各数据库建库至2016-01,语言及语种不限.由2位评价者按照纳入与排除标准独立筛选文献、提取资料、评价质量,利用Stata12.0软件对纳入研究进行统计分析及异质性检验.结果共纳入10个病例对照研究,总计病例组10700例,对照组12891例.Meta分析结果显示:MUC1 rs4072037基因各模型(A vs G:O R=1.42,95%C I:1.29-1.56,P<0.001;A A vs G G:O R=1.78,95%C I:1.52-2.08,P<0.001;AA+AG vs GG:OR=1.40,95%CI:1.21-1.61,P<0.001;A A vs A G+G G:O R=1.56,95%CI:1.38-1.76,P<0.001)均与GC的发生存在显著相关(P<0.05);在亚组分析结果显示:在种族方面,等位基因模型(A vs G:OR=1.39,95%CI:1.21-1.60),累加遗传模型(AA vs GG:OR=2.01,95%CI:1.51-2.66)及隐性模型(AA vs AG+GG:OR=1.63,95%CI:1.29-2.07)高加索人种GC患病风险均高于亚洲人种,差异具有统计学意义(P<0.05).结论 MUC1 rs4072037基因多态性与GC易感性具有一定关联,等位基因A明显增加了罹患GC的风险.MUC1 rs4072037基因对GC的早期筛查及临床诊治具有一定的应用价值.

AIM To investigate the association between the MUC1rs4072037 polymorphism and susceptibility to gastric cancer（GC） by conducting a metaanalysis.METHODS PubMed,EM BASE,The Cochrane Library,CBM,CNKI,VIP and WanFang Database were searched for published case-control studies investigating the relationship between the MUC1rs4072037 polymorphism and susceptibility to GC.Data were extracted and cross-checked from the case-control studies by two independent reviewers.Statistical analysis and heterogeneity test were conducted with Statal2.0.RESULTS Ten case-control studies including 10700 GC patients and 12891 controls were analyzed in this meta-analysis.Results indicated that allele model（A us G：OR=1.42,95%CI：1.29-1.56,P0.001）,dominant model（AA＋AG us GG：OR=1.40,95%CI：1.21-1.61,P0.001）,co-dominant model（AA us GG：OR=1.78,95%CI：1.52-2.08,P0.001）,and recessive model（AA us AG＋GG：OR=1.56,95%CI：1.38-1.76,P0.001） were strongly associated with the risk of GC.Subgroup analysis showed that allele model（A us G：OR=1.39,95%CI：1.21-1.60）,dominant model（AA us GG：OR =2.01,95%CI：1.51-2.66） and co-dominant model（AA us AG＋GG：OR=1.63,95%CI：1.29-2.07）increased the risk of GC in Caucasians.CONCLUSION The MUCl rs4072037 polymorphism is closely associated with the susceptibility to GC,and the allele A increases the risk of GC.MUCl rs4072037 polymorphism may be used as a potential biomarker for GC.