PET特异性分子探针在肝纤维化早期诊断中的应用

Research advances in the application of specific molecular probes for positron emission tomography in diagnosis of early-stage liver fibrosis

肝纤维化是许多慢性肝病的标志性过程,临床上以肝穿刺活组织检查作为肝纤维化的诊断金标准,目前缺乏无创诊断早期肝纤维化的有效手段。肝纤维化进程伴随着复杂的分子水平的物质变化,各种物质变化与肝纤维化进展程度有一定相关性。PET作为能够提供组织功能与代谢等分子水平信息的影像学检查,有能力监测这些定量化信息。简单介绍了应用于早期肝纤维化诊断的PET特异性分子探针的原理,总结了目前PET特异性分子探针对早期肝纤维化诊断、分期的应用价值,以及寻找更多、更合适的PET特异性分子探针应用于早期肝纤维化。

Liver fibrosis is a symbolic process of many chronic liver diseases,and liver biopsy is the gold standard for the diagnosis of liver fibrosis in clinical practice. At present,there is a lack of effective methods for the noninvasive diagnosis of early- stage liver fibrosis. The process of liver fibrosis is accompanied by complicated changes at the molecular level,which are associated with the progression of liver fibrosis. As an imaging examination which can provide the information at the molecular level such as tissue function and metabolism,positron emission tomography（ PET） has the ability to monitor such quantitative information. This article mainly introduces the principles of specific molecular probes for PET used in the diagnosis of early- stage liver fibrosis,summarizes the value of these specific molecular probes in the diagnosis and staging of early- stage liver fibrosis,and points out that it is necessary to find more specific molecular probes for the diagnosis of early- stage liver fibrosis.