碘-125粒子植入近程放疗在肝胆胰恶性肿瘤中的应用

Clinical effect of brachytherapy with ^(125)I seed implantation in treatment of malignant hepatopancreatobiliary tumors

碘-125(^(125)I)粒子植入在预防肝癌术后早期复发,联合其他微创治疗方法根治性治疗早期肝癌取得了很好的疗效,同时也广泛应用于中晚期肝癌及门静脉癌栓的治疗。^(125)I粒子用于治疗肝内胆管细胞癌、转移性肝癌等乏血供肿瘤,也取得了很好的局部控制率。^(125)I粒子联合胆道支架可很好的解除恶性胆道梗阻的症状,再狭窄的时间明显延长。基于^(125)I粒子植入的综合介入治疗,能显著改善胰腺癌患者的生活质量并延长生存期。^(125)I粒子植入在临床上使用方便、安全,值得推广。

Malignant hepatopancreatobiliary tumors are highly malignant and have poor prognosis.^（125）I seed implantation combined with other minimally invasive therapies for radical treatment of early liver cancer has achieved a good clinical effect in preventing early recurrence after liver cancer surgery. It is also used in the treatment of advanced liver cancer and portal vein tumor thrombosis.^（125）I seed has achieved a good local control rate in the treatment of tumors with a lack of blood supply,such as intrahepatic cholangiocellular carcinoma and metastatic liver cancer.^（125）I seed combined with biliary stenting can significantly relieve the symptoms of malignant biliary obstruction and extend the time to restenosis. Comprehensive interventional treatment based on^（125）I seed can significantly improve quality of life and extend survival time in patients with pancreatic cancer. Therefore,^（125）I seed implantation is safe and convenient in clinical practice and holds promise for clinical application.