反复肺炎患儿免疫功能与炎性因子变化分析

Analysis of the changes for immune function and inflammatory factors in children with recurrent pneumonia

目的探讨反复肺炎患儿免疫功能与炎性相关因子变化。方法选取深圳市南山区西丽人民医院2015年2月-2016年1月收治的70例反复肺炎患儿为观察组,另选同期门诊健康体检儿童70例为对照组,对所有受检者血清免疫球蛋白、T细胞亚群、炎性因子水平进行测定,对两组各项指标进行比较。结果观察组免疫球蛋白、T细胞亚群水平与对照组相比,差异有统计学意义(P<0.05);对照组炎性因子水平与观察组相比均明显较低,两组差异有统计学意义(P<0.05)。结论反复肺炎患儿免疫球蛋与T细胞亚群呈低水平表达,炎性因子呈高水平表达,其体液与细胞免疫功能紊乱,呼吸系统防御能力下降可能是反复肺炎发生的原因之一。

Objective To probe into the changes of immune function and inflammatory factors in children with recurrent pneumonia. Methods 70 children with recurrent pneumonia who accepted treatments in our hospital from February 2015 to January 2016 were selected as the observation group, and 70 children with physical healthy examined in the outpatient service were selected in the same period as the control group.The serum immunoglobulin, T lymphocyte subsets, inflammatory factor levels of all subjects were measured.Then, the indexes of the two groups were compared. Results Compared with the control group, the differences of level of immunoglobulin and T lymphocyte subsets in the observation group were statistically significant（P〈0.05）; The levels of inflammatory factors in the control group was significantly lower than that of the observation group, and the difference of the two groups was statistically significant（P 〈0.05）.Conclusion The children with recurrent pneumonia, whose humoral and cellular immune function are inordinate, have the low levels expression of immunoglobulin and T lymphocyte subsets and the high levels expression of inflammatory factor. Thus, the respiratory system defense ability decline may be one of the causes of recurrent pneumonia.