普拉洛芬联合杞菊地黄丸治疗干眼症的效果观察

Clinical effect of pranoprofen combined Qi-ju-di-huang pill in Xerophthalmia

目的研究普拉洛芬联合杞菊地黄丸治疗干眼症的临床效果。方法选取通化市五三一医院从2014年9月-2015年9月就诊的142例干眼症患者,按照就诊顺序进行排号,单号71例划入观察组,予以普拉洛芬联合杞菊地黄丸治疗,双号71例划入对照组,予以玻璃酸钠滴眼液治疗,治疗9周后,对比两组的治疗效果。结果观察组症状缓解率、基础泪液分泌、角膜荧光素染色降低率、泪膜破裂时间均大于对照组,差异具有统计学意义(P<0.05)。结论普拉洛芬联合杞菊地黄丸治疗干眼症较玻璃酸钠滴眼液有效。普拉洛芬联合杞菊地黄丸有效缓解干眼症患者症状,增加泪液分泌,延长泪膜破裂时间,减轻角膜上皮损伤。

Objective To study the clinical effect of pranoprofen combined with Qi-ju-di-huang pill in the treatment of xerophthalmia. Methods 142 cases with xerophthalmia were selected in No. 531 hospital of people liberation army from September 2014 to September 2015, and were classified two groups according to the order of treatment. The patients with odd were assigned to the observation group, treated by pranoprofen combined with Qi-ju-di-huang pill. While ones with oven numbers were assigned to the control group,treated by sodium hyaluronate eye drops. The courses of treatment were 9 weeks in both groups. The therapeutic effects of the two groups were compared after the treatments. Results Remission rate of clinical symptomatic score, tear break-up time（BUT）, decrease rate of fluorescent（FL）, Schirmer I test score were higher than those of control group. The difference was statistically significant（P 〈0.05）. Conclusion Pranoprofen combined with Qi-ju-di-huang pill was effective in treatment of dry eye of Sodium Hyaluronate Eye Drops, which could relieve symptoms of xerophthalmia and increase the secretion of tears, prolong the breakup time of tear film and alleviate the damage of corneal epithelium.