3,4-二羟基苯乙酮的合成

Synthesis of 3,4-Dihydroxyacetophenone

研究了邻苯二酚在不同条件下的Friedel-Crafts乙酰化反应。利用三氟化硼乙醚溶液作催化剂,乙酸为乙酰化试剂,合成了3,4-二羟基苯乙酮,并在此基础上,进一步对反应条件进行了优化。优化的条件为:n(三氟化硼)∶n(邻苯二酚)=1.2∶1.0,反应温度为80℃,反应时间为4 h,优化条件下,3,4-二羟基苯乙酮的收率达66.7%。

Friedel-Crafts acetylation reaction of catechol under different conditions was studied. 3,4- Dihydroxyacetophenone was synthesized using boron trifluoride/ethyl ether solution as catalyst and acetic acid as acetylation reagent, and the reaction conditions were further optimized. The optimized reaction conditions were as following： the molar ratio of BF3 to catechol was of 1.2; and the reaction temperature and time were 80℃ and 4 h, respectively. Under the optimized conditions, 3,4-dihydroxyacetophenone was obtained with a yield of 66.7%.