盐酸左氧氟沙星氯化钠注射液用于抗菌治疗时不良反应分析

Analysis of adverse reaction of Levofloxacin Hydrochloride and Sodium Chloride Injection for antimicrobial treatment

目的分析盐酸左氧氟沙星氯化钠注射液用于抗菌治疗时患者出现的不良反应特点和规律,保证患者用药安全。方法对某省级定点医院2013年6月至2015年6月期间各厂家盐酸左氧氟沙星氯化钠注射液使用后出现的46例不良反应进行分析。结果 46例不良反应中男性比例较女性偏高,60岁以上老年患者不良反应发生率最高;不良反应多发生于高剂量使用患者;临床累及器官或系统主要为皮肤及其附件损害、消化系统损害、注射部位损害;发生时间多为前30 min;偶有严重的过敏样反应。结论按说明书要求合理用药,关注特殊人群用药,密切监护患者反应,保证患者用药安全。

Objective To analyze the characteristics and rules of adverse reaction of levofloxacin hydroehloride and so- dium chloride injection for antimicrobial treatment,ensure the safety of the patients.Methods To analyze the forty-six cases of adverse reactions of levofloxacin hydrochloride and sodium chloride injection made by several manufacturers for antimicrobial treatment in a provincial hospital during June 2013 to June 2015.Results In total Forty-six cases of adverse reactions, the male proportion is higher than female, the highest incidence occurs up to 60 years or older patients ; Adverse reactions often happen at high dose of patients ; Main clinical involving organ or system are the skin and its accessories damage, digestive system damage, injection site damage ;The common time happens for the first 30 minutes ; Sometimes would occur severe allergic reactions.Conclusion Drugs should be provided reasonahle according to the instruction, and more attention should be paid to the special group of patients and their reactions, ensure the safety of the patients.