胞外囊泡及其促进胰腺癌侵袭转移的机制

Extracellular vesicles in promoting the invasion and metastasis of pancreatic cancer

胞外囊泡（EV）由原核生物及真核生物所分泌，广泛存在于血液、尿液、腹腔积液、胆汁等各种体液及肿瘤微环境中。EV 在细胞生长、运动、信号传导以及肿瘤细胞的侵袭转移中发挥重要作用。胰腺癌恶性程度高，侵袭转移能力强，EV 可通过促进细胞增殖、抑制免疫反应、促进血管形成和基质重塑等机制促进胰腺癌的侵袭转移。

The secretion of extracellular vesicles （EVs）is a well-conserved evolutionary process that occurs from prokaryotic cells to eukaryotes.EVs have been identified in body fluids such as plasma,urine,as-cites,and bile as well as tumor microenvironment.EVs play an important role in cell growth,movement,signal transduction,invasion and metastasis of tumor cells.With a high invasive ability,pancreatic cancer has a high degree of malignancy.Evs can enhance the invasion and metastasis of pancreatic cancer by increasing cell pro-liferation,inhibiting immune responses,promoting angiogenesis and extracellular matrix remodeling.