摘要
胞外囊泡(EV)由原核生物及真核生物所分泌,广泛存在于血液、尿液、腹腔积液、胆汁等各种体液及肿瘤微环境中。EV 在细胞生长、运动、信号传导以及肿瘤细胞的侵袭转移中发挥重要作用。胰腺癌恶性程度高,侵袭转移能力强,EV 可通过促进细胞增殖、抑制免疫反应、促进血管形成和基质重塑等机制促进胰腺癌的侵袭转移。
The secretion of extracellular vesicles (EVs)is a well-conserved evolutionary process that occurs from prokaryotic cells to eukaryotes.EVs have been identified in body fluids such as plasma,urine,as-cites,and bile as well as tumor microenvironment.EVs play an important role in cell growth,movement,signal transduction,invasion and metastasis of tumor cells.With a high invasive ability,pancreatic cancer has a high degree of malignancy.Evs can enhance the invasion and metastasis of pancreatic cancer by increasing cell pro-liferation,inhibiting immune responses,promoting angiogenesis and extracellular matrix remodeling.
作者
刘保瑞
吴永娜
周文策
Liu Baorui Wu Yongna Zhou Wence(First Clinical Medical School of Lanzhou University,Lanzhou 730000, Chin)
出处
《国际肿瘤学杂志》
CAS
2016年第12期947-949,共3页
Journal of International Oncology
关键词
胰腺肿瘤
肿瘤侵润
肿瘤转移
胞外囊泡
Pancreatic neoplasms
Neoplasm invasiveness
Neoplasm metastasis
Extracellular vesi-cles