Foxi蛋白对第1、2鳃弓衍生物的发育调节

The modulation of the Foxi protein on the first and second branchial arches derivatives

第1、2鳃弓是胚胎发育过程中的重要结构,可分化为颅面骨骼、耳等结构。鳃弓发育异常可导致斑马鱼、大鼠等动物产生颅面、耳等结构畸形。Forkhead(Fox)蛋白家族是胚胎发育过程中的关键转录因子,该家族中Foxi在胚胎内外胚层的不同时期有相应程度的表达,foxi1基因突变斑马鱼存在颚骨、耳板缺失及鳃弓神经嵴细胞凋亡增加等异常,Foxi1突变大鼠、狗等动物中也有相似异常。Foxi蛋白可能通过先驱因子作用调节早期胚胎发育过程中相关基因的表达,影响整个胚胎颅面结构的形成。

The first and second branchial arches are important structures in the period of embryonic development,which could differentiated into craniofacial skeleton,ear and other tissues. Abnormal branchial arches cause craniofacial,ear malformations in zebrafish,mice and other animals. Forkhead（Fox）protein family is critical transcription factors for formation of embryo,the Foxi protein expressed in embryo ectoderm and endoderm in different stages. The foxi1 mutant zebrafish display defects in otic placode and the jaw,followed by increased apoptosis of neural crest cells in arches,similar abnormities were observed in Foxi mutant mice or dogs. Foxi protein could be pioneer factors that regulate the expression of early embryonic genes,and then influence the evolution of diverse craniofacial skeleton.