急性大动脉粥样硬化性脑梗塞患者血清CRP、Hcy的表达

The significance of the expressions of serum CRP,Hcy levels on patients with acute atherosclerotic cerebral infarction

目的：探讨急性大动脉粥样硬化性脑梗塞患者血清CRP、Hcy水平变化的意义。方法：选取我院2012-05~2014-05收治的112例急性大动脉粥样硬化性脑梗塞患者为研究组,选取46例健康体检志愿者作为对照组,分别采用比浊法、循环酶法对所有研究对象进行血清C-反应蛋白（CRP）和同型半胱氨酸（Hcy）水平测定,比较检测结果,并分析其临床意义。结果：轻型49例,中型34例,重型29例,所占比例分别为43.75%、30.36%、25.89%。研究组患者颈动脉中膜厚度（ITM）测定：ITM〈1.0mm,31例,1.0mm≤ITM≤1.5mm,56例,ITM〉1.5mm：25例,所占比例分别为27.68%,50.00%,22.32%;研究组患者血清CRP、Hcy水平显著高于对照组（P〈0.05）,且神经缺损程度级别越高,血清CRP、Hcy水平越高,差异具有统计学意义（P〈0.05）,二者正向相关;研究组ITM值越大,CRP、Hcy水平越高,差异具有统计学意义（P〈0.05）,二者具有正向相关性。结论：血清CRP、Hcy水平与神经功能缺损程度和ITM正向相关,可以有效的反映急性大动脉粥样硬化性脑梗塞患者病情的严重程度,具有指导意义。

Objective： To explore the significance of the expressions of serum CRP, Hcy levels on patients with acute atherosclerotic cerebral infarction. Methods： 112 cases of patients with acute atherosclerotic cerebral infarction in our hospital from May 2012 to May 2015 were selected as study group ; and another 46 healthy volunteers were selected as control group. The turbidity method, enzymatic cycling assay were respectively used to detect the levels of serum C -reactive protein （CRP） and homocysteine （Hcy） in all subjects. The results were compared, and the significance was analyzed. Results ： The classification results of neural function in the study group were 49 mild cases, 34 moderate cases, 29 severe cases, respectively accounting for 43.75% , 30.36% , 25.89% of the total rats. The ITM determination results in the study group showed that 31 cases of ITM were less than 1.0 mm; 56 cases of ITM were from 1.0mm to 1.5mm; 25 cases of ITM were more than 1.5mm, respectively accounting for 27.68% , 50.00% and 22.32% of the total rats. The serum CRP, Hcy levels in the study group were significantly higher than those in the control group （P 〈 0. 05）. The higher the level of the degree of neurological defects, the higher the serum CRP and Hey levels. The differences were statistically significant （P 〈 0.05 ）, with positive cor- relation. The greater the carotid artery intima - media thickness （ITM） , the higher the CRP and Hcy levels. The differences were statistically significant （P 〈 0.05）, with positive correlation. Conclusion： The serum CRP and Hey levels have positive correlation with the degree of neural function defect and IMT, which can effectively reflect the severity of acute atherosclerotic cerebral infarction patients and has a guiding significance.