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CXCR3和CD4+ CD25+ CD127low调节性T细胞检测在创伤性肺损伤中的作用 被引量:3

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摘要 目的:探究CXCR3和CD4+CD25+CD127low调节性T细胞动态监测在创伤性肺损伤中作用及临床意义。方法:采用流式细胞术结合直接免疫荧光法检测30例创伤性肺损伤患者外周血T细胞表面CXCR3和CD4+CD25+CD127low调节性T细胞的表达水平。结果:创伤性肺损伤患者趋化因子受体CXCR3表达阳性率明显高于正常对照组,分别为(35.72±3.49)%和(12.19±3.89)%(P〈0.05)调节性T细胞(CD4+、CD25+、CD127low)阳性率明显低于正常对照组,分别为(11.27±1.59)%和(13.75±1.72)%(P〈0.05)。结论:CXCR3和CD4+CD25+CD127low调节性T细胞可参与创伤性肺损伤炎症的发生和发展,有可能为疾病的预防和治疗提供新思路和新途径。
出处 《黑龙江医药科学》 2016年第6期89-90,93,共3页 Heilongjiang Medicine and Pharmacy
基金 福州市卫生系统科技计划项目,编号:2013-S-W5.
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