摘要
目的:评价肿瘤相关巨噬细胞(TAM)与胃癌预后的关联。方法:检索并纳入10篇有关胃癌患者总体生存期(OS)、无病生存期(DFS)同病理组织内TAM关系的病例对照研究,使用STATA软件计算风险比(HR)和95%可信区间(CI)。结果:高TAM组与低TAM组相比,胃癌患者OS和DFS的HR值分别是1.72(95%CI:1.30-2.13,P<0.001),1.10(95%CI:0.16-2.03,P=0.022)。亚组分析显示,TAM在亚洲人和白种人胃癌OS的HR值分别是1.68(95%CI=1.25-2.11,P<0.001),2.23(95%CI=0.62-3.84,P=0.007)。结论:TAM与胃癌患者,尤其是亚洲人OS有关,与DFS关系不大。
Objective：To systematicly review the studies on the relation between tumor-associated macrophages（TAM）and the prognosis of gastric cancer（GC）.Methods：Ten studies（n=930patients）were included to estimate the relationship between TAM and the overall survival（OS）or disease free survival（DFS）of GC.Hazard ratios（HRs）and 95% confidence intervals（CIs）were calculated by the STATA software.Results：The HRof OS of GC patients with high TAM is 1.72（95% CI：1.30-2.13,P〈0.001）as compared with those with low TAM,and that of DFS is 1.10（95% CI：0.16-2.03,P=0.022）.A subgroup analysis by ethnicity revealed significant effect between TAM and a worse OS among Asians（HR=1.68,95%CI=1.25-2.11,P〈0.001）.However,the HR was 2.23（95%CI=0.62-3.84,P=0.007）for Caucasians.Conclusion：TAM could be an independent predictor for the survival of GC patients,especially for Asians.
作者
杨肖军
刘九洋
黄超群
彭春伟
陈家宽
李雁
YANG Xiaojun LIU Jiuyang HUANG Chaoqun PENG Chunwei CHEN Jiakuan LI Yan(Dept. of Ontology ＆ Hubei Clinical Study Center on CTncer, Zhongnan Hospital of Wuhan University, Wuhan 430071 , China Dept. of Surgical Oncology, Beijing Shijitan Hospital of the Capital Medical University, Beijing 100038, China)
出处
《武汉大学学报（医学版）》
CAS
2017年第1期40-43,共4页
Medical Journal of Wuhan University
基金
国家自然科学基金青年科学基金(编号:81502113)
关键词
肿瘤相关巨噬细胞
胃癌
预后
META分析
Tumor Associated Macrophages
Gastric Cancer
Prognosis
Meta-Analysis
