糖尿病患者外周血白细胞计数与胰岛素及血糖之间的关系

Association of periphery white blood cell counts with serum levels of insulin and glucose in patients with diabetes mellitus

目的:探讨糖尿病(DM)患者胰岛β细胞的功能与外周血白细胞计数之间的关系。方法:119例糖尿病患者分为I型糖尿病组(DM1)10例;II型糖尿病组(DM2)32例;妊娠性糖尿病组(GDM)55例;已发生慢性并发症糖尿病组(DC)22例;检测各组口服糖耐量试验(OGTT)胰岛β细胞分泌功能和血糖水平以及外周血白细胞分类计数。结果:DM患者男女间外周血白细胞分类计数差异无统计学意义(P>0.05),DM1、DM2、GDM组患者血清胰岛素水平明显高于DC组,且差异有统计学意义(P<0.01)。单核细胞计数与空腹胰岛素呈负相关,与餐后30 min、120min、180 min血糖值呈正相关,且P<0.05。结论:DM患者出现慢性并发症时胰岛素水平下降,降血糖治疗时应考虑到外周血单核细胞的计数。

Objective： To explore association of periphery white blood cell counts with serum levels of insulin and glucose among people with diabetes （DM）. Methods： A total of 119 DM patients were assigned to four groups： type Ⅰ diabetes （DM1, n=10）, type Ⅱ diabetes （DM2, n=32）, gestational DM （GDM, n=55） and chronic diabetic complication （DC, n=22）. Oral glucose test was use to measure serum level of insulin and glucose, followed by peripheral blood white cell counts. Results： The peripheral blood white cell counts were no significantly different （P〉 0.05） between men and women. Levels of serum insulin were significant higher in DM 1, DM2 and GDM groups than the DC group （P〈0.01）. Peripheral blood mononuclear cell counts were negatively correlated with fasting insulin level, but positively correlated with postprandial glucose levels at 0.5 h, 2 h and 3 h in all groups （ P〈 0.05）. Conclusions： The DC patients might have low serum insulin level. Peripheral mononuclear cell counts should be monitored when DM patients are on glycemic control.