S100-A8在乳腺癌表达的病理学研究

Pathological research of S100-A8 expression in breast cancer

目的:分析S100-A8在乳腺癌表达及与乳腺癌临床病理和生存状况的关系。方法:用免疫组织化学方法检测S100-A8蛋白在乳腺良性疾病(n=15)及乳腺癌无淋巴结转移组(n=83)及109例有腋窝淋巴结转移乳腺癌和配对淋巴结转移灶中的表达,进行Kaplan-Meier生存分析和Cox回归分析。结果:S100-A8蛋白在乳腺癌原发灶和淋巴结转移灶之间存在差异表达,原发癌组织和配对的转移性淋巴结之间差异有统计学意义。Kaplan-Meier生存分析和Cox回归模型提示组织学分级和淋巴结状态是乳腺癌的危险因素。结论:S100-A8蛋白与乳腺癌淋巴结转移相关,并与ER表达水平和组织学类型有关。

Objective：To analyze S100-A8 expression in breast cancer and relation to clinicopathological index and survival status of breast cancer. Methods： Immunohistochemical method was applied to observe and assess expression of protein S100-A8 in benign breast disease （n=15）, primary breast cancer without lymph node metastasis （n=83）, primary breast cancer with lymph node metastasis （n=109）, and paired metastatic lymph nodes （n=109）. The staining score was evaluated and Kaplan-Meier analysis and Cox hazard regression analysis were utilized to investigate the relationship between expression of protein S100- A8 and survival status of breast cancer patients. Results： Protein S100-A8 was found to be differently expressed between primary cancer tissue and metastatic lymph nodes. The statistical significant difference between primary cancer tissue and paired metastatic lymph nodes was found. Kaplan-Meier analysis and Cox hazard regression model suggested that histological grade and nodal status were risk factors of breast cancer. Conclusion： Protein S100-A8 is related with breast cancer lymph nodes metastases, and it is related to the level of ER expression and histological type.