左氧氟沙星联合阿莫西林四联方案根除幽门螺杆菌感染慢性胃炎疗效观察

Effect observation of Levofloxacin and Amoxicillin quadruple therapy for eradicating chronic gastritis of Helicobacter pylori

目的：观察左氧氟沙星联合阿莫西林标准四联方案根除幽门螺杆菌的临床疗效。方法：经胃镜及C13呼气试验确诊幽门螺杆菌感染的慢性胃炎患者250例,随机分为2组,观察组予左氧氟沙星＋阿莫西林＋PPI＋铋剂,对照组以克拉霉素＋阿莫西林＋PPI＋铋剂四联治疗方案,治疗2周,观察不良反应发生情况、临床症状缓解情况。根除治疗结束4~6周后复查C13呼气试验,评估幽门螺杆菌根除成功率。结果：左氧氟沙星组及克拉霉素组根除幽门螺杆菌的成功率为92.50%和76.92%,不良反应发生率为4.17%和19.23%,两组比较差异有统计学意义（P〈0.05）。结论：左氧氟沙星联合阿莫西林四联方案根除幽门螺杆菌优于克拉霉素＋阿莫西林＋PPI＋铋剂四联治疗方案。

Objective： To observe the clinical curative effect of Levofloxacin combined with Amoxicillin standard quadruple therapy for eradication of Helicobacter pylori. Methods： 250 cases of chronic gastritis with Helicobacter pylori infection diagnosed by gastroscopy and C13 breath test were randomly divided into two groups, the observation group was treated with Levofloxacin ＋ Amoxicillin ＋PPI＋ bismuth agent,the control group with Clarithromycin ＋ Amoxicillin ＋PPI＋ bismuth agent. The two groups were treated for 2 weeks. The occurrence of adverse reactions and the situation of clinical symptoms to ease were observed The eradication of 4-6 weeks by the C13 breath test in hospital after the end of treatment, success rate of Helicobacter pylori eradication was evaluated. Results： The success rate of Helicobacter pylori eradication in the observation group and control group were 92.50% and 76.92%, the incidence of adverse reactions in the two groups were 4.17% and 19.23%, the difference between two groups was statistically significant （P 〈 0.05 ）. Conclusion： Levofloxacin and Amoxicillin quadruple therapy for eradicating Helicobacter pylori bacteria is better than Clarithromycin and Amoxicillin ＋PPI＋ bismuth quadruple therapy.