阿霉素对脑恶性胶质瘤间质化疗研究进展

Research progress of adriamycin on interstitial chemotherapy for malignant glioma

脑胶质瘤是中枢神经系统发病率最高的肿瘤,且呈恶性浸润性生长,具有高病死率及高复发率,是神经外科最难治的肿瘤之一。目前对脑恶性胶质瘤的治疗以手术切除,术后放化疗为主。由于肿瘤的生长特征,手术全切难度大;静脉化疗由于受到血脑屏障及药物全身毒性的限制,使得常规的治疗方案效果不佳。广谱抗肿瘤药物阿霉素对脑恶性胶质瘤细胞有较强的杀伤效果,间质化疗能绕过血脑屏障阻碍,同时无全身化疗的不良反应,有望成为控制脑胶质瘤术后局部复发的有效治疗手段。笔者就阿霉素对脑恶性胶质瘤间质化疗的理论基础、化疗方法、相关实验研究进展进行综述。

Glioma has the highest incidence of tumors in central nervous system, which in malignant invasive growth, and with a high mortality and high rate of recurrence, become one of the most intractable tumor of neurosurgery. Currently, the treatment of malignant glioma is surgical resection, postoperative radiation and chemotherapy. However, due to the characteristics of tumors growth, total removal is difficult,intravenous chemotherapy is limited to the blood-brain barrier(BBB) and systemic toxicity, so which lead the regular treatment to poor effect. Broad-spectrum antitumor drug doxorubicin, have intensive effect to the glioma cells. Interstitial chemotherapy can bypass the BBB effectively, which can reduce the side effect of the systemic body from chemotherapy at the same time, and will become the effective treatment of local recurrence of the glioma probably. Auther reviews the theoretical foundation, chemotherapy method, and the progress of the related experiment on Adriamycin to the interstitial chemotherapy of malignant glioma.