DNA甲基化在组织/体液来源鉴定中的研究进展

Research advances of forensically fluid/tissues identification based on DNA methylation analysis

对可疑生物样本的组织/体液进行来源鉴别是重建犯罪现场、推断犯罪性质等侦查活动中极为重要的一环。对表观遗传学理论的研究证明运用基因组中存在的组织特异性DNA甲基化差异位点(t DMRs)可以对组织/体液进行来源鉴别。本文旨在通过对近年来DNA甲基化在法医学领域用于鉴定人体组织/体液来源方面的研究成果进行阐述,试图用所得到的信息来分析DNA甲基化作为一种组织/体液鉴定遗传学标记的可能性、优劣点及其应用价值和发展前景,以期能为法医工作者的相关研究及实践提供参考。

Identification of tissues/body fluids in forensic science is important for criminal cases investigation such as crime scene reconstruction, conclude the character of crime. Recently, many researches of Epigenetic shows that tissue specific differentially methylated regions（tDMRs） have the ability to as a biomarker for identification of tissues/ body fluids. In this paper, we reviewed the study progress and summarized the probability, advantage and disadvantage as well as application value and the development direction of the application of DNA methylation in the aspect of identifying the tissues/body fluids source, aiming at providing a reference for the related research and application.