尼莫地平联合丁苯肽防治急性脑梗死后血管性认知障碍的效果及作用机制分析

Effect and mechanism analysis of nimodipine combined with SBR in prevention from vascular cognitive impairment of acute cerebral infarction

目的对尼莫地平联合丁苯肽在防治急性脑梗死后血管性认知障碍(vascular cognitive impairment)中的效果进行评价,并分析其作用机制。方法将120例住院的脑梗死患者,随机分为治疗组和对照组,所有患者均采用常规治疗,试验组在此基础上给予尼莫地平联合丁苯肽口服药物防治。治疗后3个月进行MOCA认知评估量表评测,根据评分判定认知障碍。结果两组在治疗前评分无统计学差异(P=0.697),但在治疗3月后治疗组MOCA量表评分较对照组的升高有统计学意义(P<0.001)。对照组中15例患者存在血管性认知障碍,治疗组为5例。MOCA认知水平的影响因素为年龄、教育程度、病体积和有无白质病变(P<0.05)。结论尼莫地平与丁苯肽联合防治是降低血管性认知障碍(VCI)发生的有效手段,能够作为防治VCI这一进行性疾病的重要防治措施。

Objective To evaluate the effect of nimodipine combined with SBR in the prevention and treatment of cognitive impairment vascular in patients with acute cerebral infarction,and to analyze its mechanism.Methods 120 hospitalized patients with cerebral infarction were randomly divided into treatment group and control group,all patients were treated with routine treatment,and the experimental group was given nimodipine combined with oral administration of the drug. After 3 months of treatment,the MOCA cognitive assessment scale was evaluated,and cognitive impairment was judged according to the score. Results There were no differences emerged in the score,but in the course of the treatment group Mo CA 3m scale scores than the control group increased statistically significant. 15 cases of vascular cognitive impairment occured in the control group,the treatment group compared with 5 cases. Conclusions The prevention and treatment of nimodipine and styrenebutadiene-peptide is an effective means to reduce the occurrence of vascular cognitive impairment（ VCI）,and can be used as an important control measures for the prevention and treatment of VCI disease.