磷酸肌酸钠静脉用药引起新生儿低钙血症的临床分析

Clinical analysis of neonatal hypocalcemia related to creatine phosphate sodium via venous injection

目的探讨磷酸肌酸钠静脉给药时引起新生儿低血钙的原因。方法选取2014年在我院接受磷酸肌酸钠治疗的新生儿80例,分为2组,各40例。观察组采用建议剂量治疗(1.0 g·d^(-1),iv gtt,qd);对照组采用下调药物剂量(0.25~0.5 g·d^(-1),iv gtt,qd)治疗。比较2组治疗前后新生儿血钙的变化。结果观察组用药3 d后血钙水平低于用药前,多见于早产儿及早期新生儿。药物减量后用药前后血钙水平未见明显差异,并且不影响治疗效果。结论大量磷酸盐摄入可能会影响钙代谢,导致机体钙磷代谢失衡,从而引起低钙血症;因此,磷酸肌酸钠静脉给药时应检测血钙水平,并酌情下调用药剂量。

AIM To explore the cause that creatine phosphate sodium for injection lead to neonatal hypocaleerrfia. METHODS Totally 80 neonates who were treated with creatine phosphate sodium for injection in our hospital were divided into 2 groups, each group of 40 neonates. The deference of calcium between group one （recommended dosage） that was administrated with creatine phosphate sodium intravenously, 1 g, qd and group two that was administrated with crea- tine phosphate sodium intravenously, 0.25 - 0.5g, qd was compared. RESULTS The calcium decreased significantly in group one after 3 d with creatine phosphate sodium treatment, especially for preterm infants and newborns. The group two had no deference. CONCLUSION Excessive phosphate intake may influence metabolism of calcium, therefore it should be monitored when newborns were treated with creatine phosphate sodium, and the dosage should be reduced if it is necessary.