肺炎支原体肺炎后患儿发生反复呼吸道感染的影响因素研究

Influencing factors of recurrent respiratory tract infections in patients after mycoplasma pneumonia

目的探讨儿童肺炎支原体肺炎后发生反复呼吸道感染的相关影响因素。方法选取2013年1月至2014年12月收治的150例肺炎支原体肺炎治愈的患儿,跟踪随访1年,分别在治愈后3、6、9、12个月时检测肺炎支原体IgM与肺炎支原体IgG抗体滴度、免疫功能、记录用药情况、分析肺炎支原体肺炎治愈后反复呼吸道感染的相关因素。结果行为期1年的跟踪随访,150例患儿中治愈后68例发生反复呼吸道感染,占45.52%。肺炎支原体肺炎组患儿发生反复呼吸道感染的年龄、CD4/CD8、IgA、IgG、IgM及是否服用增强免疫力药物与非反复呼吸道感染患儿比较差异有统计学意义(P<0.05)。结论肺炎支原体肺炎患儿治愈后发生反复呼吸道感染与患儿的年龄、肺炎支原体抗体、免疫力指标都有相关性,使用免疫增强剂可有效降低反复呼吸道感染的发生率。

Objective To investigate the influencing factors of recurrent respiratory tract infections in patients after mycoplas-ma pneumonia. Methods From January 2013 to December 2014,150 patients with mycoplasma pneumonia cured were followed up for 1 year,the mycoplasma pneumoniae IgM and IgG antibody titers after 3,6,9,12 months and immune functions were de-tected,the related factors of recurrent respiratory infections after mycoplasma pneumonia were analyzed. Results Followed up for 1 year,68 patients with recurrent respiratory tract infections,accounting for 45. 52% . There were significant differences in the age,CD4 / CD8,IgA,IgG,IgM,and whether to take enhanced immunity drugs between the patients with recurrent respirato-ry tract infections after mycoplasma pneumonia with the patients without recurrent respiratory tract infections after mycoplasma pneumonia（P 〈 0. 05）. Conclusion Recurrent respiratory tract infections in children are correlated with the age of mycoplasma pneumoniae pneumonia in children,mycoplasma pneumoniae antibody,immunity indicators,and immune enhancer can effective-ly reduce the incidence of recurrent respiratory tract infections.