CD44、CD47和c-met在卵巢透明细胞癌中的表达及意义

Expressions of CD44,CD47,and c-met in Ovarian Clear Cell Carcinoma and Their Clinical Significance

目的探讨CD44、CD47和c-met在卵巢透明细胞癌组织中的表达及其与患者的临床病理参数及预后的关系。方法采用免疫组织化学检测86例卵巢透明细胞癌组织中CD44、CD47和c-met的表达,进一步分析其与卵巢透明细胞癌临床病理参数及预后的关系,分析三者表达的相关性。结果卵巢透明细胞癌组织中CD44、CD47和c-met呈过表达,阳性表达率分别为90.7%、91.9%、94.2%,CD44、CD47的强阳性表达均与卵巢透明细胞癌的分期晚、化疗耐药及预后不良相关(P均<0.05),c-met的强阳性表达均与化疗耐药及预后不良相关(P<0.05),CD44、CD47的强阳性表达均与淋巴结转移无关。COX分析表明临床分期晚及CD44、CD47和c-met高表达是卵巢透明细胞癌预后独立风险因素(P均<0.05)。相关性分析显示,CD44与CD47、c-met及CD47与c-met间的表达均呈显著正相关(Spearman相关系数rs分别为0.783、0.776、0.835,P均<0.01)。结论 CD44、CD47和c-met在卵巢透明细胞癌中高表达且两两相关,是其不良预后独立危险因素。

Objective To investigate the expressions of CD44,CD47,and c-met in ovarian clear cell carcinoma（ OCCC） tissue and their correlations with clinical variables and prognosis. Methods Immunohistochemical method was used to investigate the expressions of CD44,CD47,and c-met in tissues from 86 OCCC patients and the relationships of their expressions with the clinicopathological factors of OCCC were analyzed.Results The expressions of CD44, CD47, and c-met were significantly high in OCCC tissues（ 90. 7%,91. 9%,and 94. 2%,respectively）. The strong positive expressions of CD44 and CD47 were significantly correlated with advanced International Federation of Gynecology and Obstetrics stages,chemotherapeutic resistance,and poor prognosis（ all P〈0.05）,the strong positive expression of c-met was significantly correlated with chemotherapeutic resistance and poor prognosis（ all P〈0.05）,whereas there was no correlation between the strong positive expressions of CD44,CD47,and c-met and the lymphatic node metastasis. COX survival analysis revealed that advanced International Federation of Gynecology and Obstetrics stages and high expressions of CD44,CD47 and c-met were independent risk factors for poor prognosis（ P〈0.05）. There was a positive correlation between CD44（ or CD47） and c-met and between CD44 and CD47（ the Spearman correlation coefficient rswas0. 783,0. 776,and 0. 835,respectively,all P〈0.01）. Conclusions The expressions of CD44,CD47,and c-met increase in OCCC tissues and are correlated with each other. High expressions of CD44,CD47,and c-met are independent factors for poor prognosis.