摘要
A thinner cortex has higher potential for binding GABA receptor A which is associated with larger amplitudes of intrinsic brain activity(i BA). However, the relationship between cortical thickness and i BA is unknown in intact and epileptic brains. To this end, we investigated the relationship between cortical thickness measured by highresolution MRI and surface-based i BA derived from resting-state functional MRI in normal controls(n = 82) andpatients with generalized tonic–clonic seizures(GTCS)only(n = 82). We demonstrated that the spatial distribution of cortical thickness negatively correlated with surface-based i BA amplitude at both whole-brain and within independent brain functional networks. In GTCS patients,spatial coupling between thickness and i BA amplitude decreased in the default mode, dorsal attention, and somatomotor networks. In addition, the vertex-wise acrosssubject thickness–i BA amplitude correspondence altered in the frontal and temporal lobes as well as in the precuneus in GTCS patients. The relationship between these two modalities can serve as a brain-based marker for detecting epileptogenic changes.
A thinner cortex has higher potential for binding GABA receptor A which is associated with larger ampli- tudes of intrinsic brain activity （iBA）. However, the rela- tionship between cortical thickness and iBA is unknown in intact and epileptic brains. To this end, we investigated the relationship between cortical thickness measured by highresolution MRI and surface-based iBA derived from resting-state functional MRI in normal controls （n = 82） and patients with generalized tonic-clonic seizures （GTCS） only （n = 82）. We demonstrated that the spatial distribution of cortical thickness, negatively correlated with surface-based iBA amplitude at both whole-brain and within independent brain functional networks. In GTCS patients, spatial coupling between thickness and iBA amplitude decreased in the default mode, dorsal attention, and somatomotor networks. In addition, the vertex-wise across-subject thickness-iBA amplitude correspondence altered in the frontal and temporal lobes as well as in the precuneus in GTCS patients. The relationship between these two modalities can serve as a brain-based marker for detecting epileptogenic changes.
作者
Wei Liao
Jue Wang
Ting Xu
Zhiqiang Zhang
Gong-Jun Ji
Qiang Xu
Zhengge Wang
Fang Yang
Xi-Nian Zuo
Anqi Qiu
Yu-Feng Zang
Guangming Lu
Huafu Chen
Wei Liao;Jue Wang;Ting Xu;Zhiqiang Zhang;Gong-Jun Ji;Qiang Xu;Zhengge Wang;Fang Yang;Xi-Nian Zuo;Anqi Qiu;Yu-Feng Zang;Guangming Lu;Huafu Chen(Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China;Key Laboratory for Neuroinformation of Ministry of Education,Center for Information in BioMedicine, School of Life Scienceand Technology, University of Electronic Science and Technology of China, Chengdu 610054, China;Department of Psychology, School of Education, Hangzhou Normal University, Hangzhou 310015, China;Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China;Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China;Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China;Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210002, China;Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China;Department of Biomedical Engineering and Clinical Imaging Research Center, National University of Singapore, Singapore 117583, Singapore)
基金
supported by the National High Technology Research and Development Program of China(2015AA020505)
the Natural Science Foundation of China(61533006,81201155,81301198,81471653,81401400,81271553,and 81422022)
the Fundamental Research Funds for the Central Universities(ZYGX2013Z004)
the China Postdoctoral Science Foundation(2013M532229)
