补肾解郁方治疗肾虚肝郁女性卵巢储备功能下降26例临床观察

Clinical Observation of Bushen Jieyu Recipe Treatment for Shen deficiency Gan stagnation model Diminished Ovarian Reserve 26 cases

[目的]观察补肾解郁方治疗肾虚肝郁女性卵巢储备功能下降疗效。[方法]使用前瞻性设计方法,26例门诊患者补肾解郁方(熟地黄10g,山茱萸6g,女贞子10g,墨旱莲、菟丝子15g,茯苓12g,紫石英15g,鹿角胶(烊化)10g,柴胡9g,白芍、香附、牛膝10g),1剂/d,水煎400m L,早晚口服;经期停用,连续治疗3个月为1疗程。观测临床症状、月经周期、FSH、LH、E2、FSH/LH、不良反应。连续治疗2疗程,判定疗效。[结果]痊愈6例,显效11例,有效7例,无效2例,总有效率92.30%(24/26)。妊娠5例。FSH、LH/FSH均有改善(P<0.01),LH、E2无明显改善(P>0.05)。[结论]补肾解郁方治疗肾虚肝郁女性卵巢储备功能下降,疗效满意,无严重不良反应,值得推广。

[Objective] To observe clinical effect of Bushen Jieyu Recipe in Diminished Ovarian Reserve（DOR）. [Method] Use the prospective design method, 26 cases of clinic patients with the Bushen Jieyu Recipe （Shudihuang 10g, Shanzhuyu 6g, Nvzhenzi lOg, Mohanlian 15g,Tusizi 15g, Fulin 12g, Zishiying 15g, Lujiao 10g （melting by heat）, Chaihn 9g, Baishao lOg, Cuxiangfu 10g, Niuxi 10g） one recipe per day, fried 400 ml water, take every morning and evening except menstrual period. Continuous treatment for 3 months was a course. Observe the changes of clinical symptoms, the value of FSH, LH, E2, the rate of FSH/LH and the adverse reactions. Judge the clinical effect in continuous 2 courses of treatment. [Results] Cured 6 cases, markedly effective 11 cases, effective 7 cases, ineffective in 2 cases. The total effective rate was 92.30% （24/26）. Pregnancy in 5 cases. LH/FSH, FSH are improved （P〈0.01）, LH, E2 no significant improvement （P〉0.05）. [Conclusion] Clinical effect with the method of Bushen Jieyu Recipe in DOR was satisfied,no serious adverse reactions, worthy of promotion.