黄根抗肝纤维化活性部位的化学成分研究

Chemical constituents in anti-hepatic fibrosis extracts from root of Prismatomeris tetrandra(Roxb.) K.Schum

目的：研究黄根Prismatomeris tetrandra（Roxb.）K.Schum的化学成分。方法：通过反复的硅胶柱色谱进行分离纯化,根据理化性质和波谱数据进行结构鉴定。结果：从黄根的乙酸乙酯萃取部位分离鉴定了7个化合物：东莨菪内酯（1）、豆甾-4-烯-3-酮（2）、去甲虎刺醛（3）、2-羟甲基-3-羟基-9,10-蒽醌（4）、甲基异茜草素（5）、甲基异茜草素-1-甲醚（6）、胡萝卜苷（7）。结论：化合物1-4为首次从该植物中分离得到。

Objective： To investigate the chemical constituents in anti-hepatic fibrosis extracts from root of Prismatomeris tetrandra（Roxb.） K. Schum. Methods： Compounds were isolated by chromatographic techniques on silica gel column. Their structures were elucidated by chemical and spectral methods. Results： Seven compounds were identified： scopoletin（1）,stigmast-4-en-3-one（2）,nordamnacatal（3）,2-hydoxymethyl-3-hydroxyan thraquione（4）,rubiadin（5）,rubadin-1-methyl ether（6）,and daucosterol（7）. Conclusion：Compounds 1 - 4 were isolated from the plant for the first time.