摘要
Engineered magnetic nanosystems exhibit attractive options for implementing unique diagnostic options and therapeutic solutions in biomedical applications. Here we report a facile, thermo-free and aqueous synthetic method to prepare ascorbic acid-stabilized iron-platinum nanoparticles. The effects of reducing agent, pH and sequence of precursor addition are investigated, and optimized reaction condition is identified to obtain a unique iron-platinum （Pt-FePt） nanosystems. The multifunctionality of the developed nanosystem has been realized by catalytic efficiency of platinum for therapeutic application and superparamagnetic property of FePt for magnetic resonance imaging contrast enhancement. Moreover, the multifunctional imaging and therapeutic activities have been achieved at physiological pH. The developed multifunctional nanoparticles are monodisperse with uniform morphology as well as stable in solution and non-toxic.
Engineered magnetic nanosystems exhibit attractive options for implementing unique diagnostic options and therapeutic solutions in biomedical applications. Here we report a facile, thermo-free and aqueous synthetic method to prepare ascorbic acid-stabilized iron-platinum nanoparticles. The effects of reducing agent, pH and sequence of precursor addition are investigated, and optimized reaction condition is identified to obtain a unique iron-platinum （Pt-FePt） nanosystems. The multifunctionality of the developed nanosystem has been realized by catalytic efficiency of platinum for therapeutic application and superparamagnetic property of FePt for magnetic resonance imaging contrast enhancement. Moreover, the multifunctional imaging and therapeutic activities have been achieved at physiological pH. The developed multifunctional nanoparticles are monodisperse with uniform morphology as well as stable in solution and non-toxic.
基金
supported by the Dept. of Biotechnology (DBT), Govt. of India vide Grant No. BT/PR10874/ NNT/28/136/2008
Dept. of Science and Technology (DST), Govt. of India for INSPIRE Fellowship
