中性粒细胞/淋巴细胞比值联合颈动脉斑块对稳定型心绞痛的预测价值探讨

Predictive value of neutrophil lymphocyte ratio combined with carotid plaque for stable angina

目的探讨中性粒细胞/淋巴细胞比值(NLR)联合颈动脉斑块对稳定型心绞痛的预测价值。方法入选2014年1月—2015年12月在我科因胸痛住院并颈动脉有斑块患者共260例,所有患者均行冠脉造影检查,将NLR值由小到大排列,采取中位数分类法分为2组:A组NLR≥3.45;B组NLR<3.45。比较2组患者冠心病检出率,以及白细胞计数(WBC)、空腹血糖(FPG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的差异。结果 A组与B组冠心病检出率有统计学差异(P<0.01),2组患者TC、LDL-C比较有统计学差异(P<0.01);WBC、FPG、HDL-C比较无统计学差异(P>0.05)。ROC曲线分析发现NLR对冠心病有预测价值,其诊断最佳Cut-off值为3.40,敏感度为60.3%、特异度为75.4%。结论 NLR联合颈动脉斑块对稳定型心绞痛具有预测价值。

Objective To discuss the predictive value of neutrophil lymphocyte ratio combined with carotid plaque for stable angina.Methods From January 2014 to December 2015,a total of 260 patients with carotid plaque were hospitalized in our department for chest pain.All patients received coronary angiogram. According to the neutrophil lymphocyte ratio（NLR）value,they were divided into group A（NLR≥3.45）and B（NLR〈3.45）by taking the median classification. The detection rates of coronary heart disease,white blood count（WBC）,total cholesterol（TC）,and High-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,and blood glucose were compared between the groups.Results There were significant differences in the detection rates of coronary heart disease（P〈0.01）,TC,and LDL-Cbetween group A and B（P〈0.01）.No significant differences in WBC,HDL-C,and blood glucose were observed between the groups（P〉0.05）.ROC analysis revealed that NLR had a predictive value for coronary heart disease.The cut-off value of diagnosis was 3.40,the sensitivity was 60.3%,and the specificity was 75.4%. Conclusion Combined with carotid plaque,NLR has its own predictive value for stable angina.