利格列汀治疗糖尿病肾病的临床疗效观察

The investigation about the clinical effects of Linagliptin on diabetic nephropathy

目的观察利格列汀治疗糖尿病肾病的疗效。方法选择我院2014年8月—2015年12月收治的糖尿病肾病患者60例,随机分为观察组和对照组,每组30例。对照组给予二甲双胍联合伏格列波糖治疗,观察组给予利格列汀(5 mg,1次/d)联合二甲双胍和伏格列波糖治疗,4个月为1个疗程。1个疗程后观察2组治疗前后空腹血糖(FPG)、糖化血红蛋白(HbA_1c)、24 h尿蛋白定量(24 h-Upro)、血清白蛋白(Alb)、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、血肌酐(SCr)、胱抑素C(Cys-C)的变化。结果治疗4个月后,2组FPG、Hb A1c、24 h-Upro、Alb、TC、TG、LDL均较治疗前明显改善,且观察组以上指标及SCr、Cys-C水平的改善程度明显优于对照组,差异均有统计学意义(P<0.05)。结论利格列汀治疗糖尿病肾病能有效降低血糖,并能显著降低蛋白尿,延缓肾衰竭进展。

Objective To investigate the clinical efficacy of linagliptin injection in the treatment of diabetic nephropathy （DN）.Methods 60 cases of DN patients admitted in our hospital from Aguest 2014 to December 2015 were selected and randomly divided into the observe group and control group （n=30）.In the control group,the patients were treated with metformin combined with voglibose.At the same time,the patients in the observe group were treated with linagliptin（5 mg,once a day）combined with metformin and voglibose on the base of the control group for 4 monthes. 4 monthes later,The levels of fasting blood glucose （FBG）,glycosylated hemoglobin （HbA1c）,24-hour urine protein （24h-Upro）,albumin （Alb）,total cholesterol （TC）,triglycerides （TG）,low density lipoprotein cholesterol（LDL-C）, serum creatinine （Scr） and cystatin C （Cys-C） were observed and recorded before and after the treatment. Results After 4 monthes treatment,the FBG、HbA1c、24h-Upro、Alb、TC、TG、HDL-C levels were significantly improved after treatment of both groups （P〈0.05）,and the above index as weel as Scr、Cys-C levels of the observe group were more significantly improved than those of the control group （P〈0.05）.Conclusion Linagliptin not only effectively controlblood sugar of diabetic nephropathy,but also can reduce urine protein leakage,which delays the development of diabetic nephropathy.