育龄女性甲亢患者碘-131治疗前后血清性激素水平及生育随访研究

On serum hormone levels in hyperthyroidism women in childbearing age before and after Treatment with Iodine-131

目的研究育龄女性甲亢患者碘-131治疗前后血清性激素水平及生育随访结果。方法选取2010年1月—2015年1月我院诊治的80例育龄女性甲亢患者临床资料,将行碘-131治疗的患者40例设为研究组,将行抗甲状腺药物治疗的患者40例设为对照组,同期选择接受体检的45例健康育龄女性资料,设为空白组,分析治疗前后血清性激素及随访生育情况。结果研究组治疗前血清性激素水平与空白组比较,均显示高度差异(P<0.01),研究组与对照组治疗前相关指标无明显差异(P>0.05);治疗后研究组FSH、LH、E2、P、T、PRL指标均较治疗前显著改善且程度优于对照组(P<0.05);同时,研究组治疗后随访要求生育及成功生育比例略低于空白组,但比较无明显差异(P>0.05)。结论育龄女性甲亢患者接受碘-131治疗后血清性激素指标水平与行抗甲状腺药物治疗者差异明显,且其与健康妇女相比并未对生育功能产生不良影响。

Objective To study the level of serum hormone in hyperthyroidism women in child-bearing age before and after the treatment with Iodine 131 and report the follow-up fertility results. Methods The clinical data of 45 healthy women in childbearing age who had received medical examination in our hospital between January 2010 and January 2015 were reviewed, and were set as the control group. The clinical data of another 80 women in childbearing age yet with hyperthyroidism treated in our hospital during the same period were reviewed, and were divided into two groups, with those who had received antithyroid therapy as study group A and those given Iodine-131 for treatment as study group B. The immediate curative effects of study group A and B were compared, so were the serum hormone levels and follow-up fertility results before and after treatment in the three groups. Results The total immediate effectiveness in study group B was 92.50%, higher than that in the control group, which was 77.50%（P〈0.05）. Before the treatment, serum hormone levels in study group A and B were both significantly higher than the control group （P〈0.01）. In addition, after treatment, levels of indexes including FSH, LH, E2 and PRL in the study group A, and FSH, LH, E2, P, T and PRL levels in study group B were significantly improved than before the treatment （P〈0.05）. The success rate of reproduction in the study group was lower than that in the control group A （P〈0.05）, but was no significant difference with study group B（P〉0.05）. Conclusion Iodine 131 is with significant treatment effect for hyperthyroidism women in child-bearing age, it also can effectively improve the serum hormone level, yet produces no adverse effects on the reproductive function of the patients, thus it is with the value of clinical application.