阿托伐他汀治疗ACS患者的血脂水平和hsCRP变化分析

The effective of Atorvastatin on lipid levels and hypersensitive c-reactive protein in patients with acute coronary syndromes changes

目的观察阿托伐他汀治疗对于急性冠脉综合征(ACS)患者血脂水平和超敏C反应蛋白(hs CRP)的影响。方法本试验采用前瞻性开放性病例对照研究,将84例急性冠脉综合征患者随机分为2组:常规治疗组(41例)采用常规治疗;阿托伐他汀治疗组(43例)在常规药物治疗基础上,加用阿托伐他汀(20 mg/d)治疗,在治疗前以及治疗3个月后检测患者血脂及超敏C反应蛋白水平。结果常规治疗对血脂和超敏C反应蛋白水平无明显影响;阿托伐他汀不但能降低血脂水平,还显著降低C反应蛋白水平。结论阿托伐他汀可改善急性冠脉综合征患者血脂水平,并具有抗炎作用,对于抑制心肌缺血的进展具有良好作用。

Objective To observe the atorvastatin treatment on blood lipid levels in patients with acute coronary syndromes and the impact of c-reactive protein. Methods this experiment adopts the prospective open case-control study,84 cases of patients with acute coronary syndrome were randomly divided into 2 groups：41 cases with conventional treatment; 43 cases on the basis of conventional drug treatment,combined with atorvastatin treatment（20 mg/d）,before treatment and after treatment for 2 months testing in patients with blood lipid and hypersensitive c-reactive protein level. Results The conventional treatment of blood lipid and hypersensitive c-reactive protein level had no obvious effect; Atorvastatin can not only reduce blood lipid levels,also significantly lower levels of c-reactive protein. Conclusion Atorvastatin improve lipid levels in patients with acute coronary syndrome,and have anti-inflammatory effect,has good effect for the progress of the inhibition of myocardial ischemia.