142株鲍曼不动杆菌区域性分布及耐药特点的分析

Analysis of Regional Distribution and Drug Resistance Characteristic of 142 Strains of Acinetobacter Baumannii

目的：了解鲍曼不动杆菌区域性分布及耐药特点，为临床治疗提供依据。方法：对2013年1-12月笔者所在医院住院感染患者分离出的鲍氏不动杆菌及其耐药性进行分析，药敏试验采用稀释法以MIC（最低抑菌浓度）报告。结果：在76例感染患者中，分离出了142株的鲍氏不动杆菌，主要来源科室为ICU，占28．9％；标本来源以呼吸道分泌物最多，占92．3％；感染率以恶性肿瘤患者最高，占36．8％；鲍曼不动杆菌对头孢西丁、头孢唑啉、头孢噻肟耐药率最高，依次为99．3％、990％、98．6％；对头孢他啶、头孢吡肟、亚胺培南、阿米卡星、庆大霉素、妥布霉意、复方新诺明、环丙沙星、左旋氧氟沙星耐药率在20％～45％。结论：鲍曼不动杆菌对多种常见抗菌药物的耐药率呈上升趋势，应动态监测和掌握鲍曼不动杆菌的分布及耐药特点，指导临床合理使用抗菌药物，以减少或延缓多重耐药菌株的产生。

Objective： To understand the regional distribution and drug resistance characteristic of acinetobacter baumannli in order to provide the basis for clinical treatment.Method： The acinetobacter baumannii was isolated from the patients in our hospital in 2013.MIC （minimum inhibitory concentration） was used to evaluate the outcomes of drug sensitive test performed by dilution method.Result： 142 strains of aeinetobacter baumannii were isolated from 76 infectious patients, 28.9% of which were derived from ICU.92.3% of these specimen were derived fi＇om respiratory secretions.36.8% of the strains were derived from the patients suffered from malignancy.The resistance rate of acinetobacter baumannii to cefoxitin, cefazolin and cefotaxime was sequenced from high to low as 99.3%, 99.3%, 98.6%, meanwhile, the resistance rate of ceftazidime, cefotaxime, imipenem, amikacin, gentamycin, tobramycin, cotrimoxazole, ciprofloxaein, levofloxacin was range from 20% to 45%.Conclusion： The resistance rate of acinetobactar baumannii to a variety of common antimicrobial displays an upward tendency.The distribution and antibiotic resistance characteristic should be dynamic monitored and controlled to guide the rational use of antimicrobial in clinical so as to decrease or postpone the appearance of multiple drug-resistant strains.