系统性红斑狼疮患者全血细胞分析及其与抗ds-DNA抗体的相关性

Correlation between anti-ds-DNA antibody and complete blood count parameters in SLE

目的:探讨系统性红斑狼疮(SLE)患者抗ds-DNA抗体与全血细胞计数相关参数的关系。方法:回顾性选取SLE患者62例,同期健康体检者50例为研究对象。间接免疫荧光法测定抗ds-DNA抗体,全自动血液分析仪测定全血细胞计数,分析抗ds-DNA抗体与全血细胞计数各参数的相关性。结果:抗ds-DNA抗体阳性低滴度组和阴性组比较,白细胞计数及其分类计数降低;抗ds-DNA抗体阳性高滴度组比低滴度组大血小板比率和血小板体积分布宽度明显增加;红细胞分布宽度变异系数在抗ds-DNA抗体阴性组和阳性低滴度组之间,阳性低滴度组和高滴度组之间差异有统计学意义(P<0.05)。结论:外周全血细胞分析是监测SLE患者病情发展的简单实用检查,尤其红细胞分布宽度变异系数能全程反映SLE患者病情的变化。

Objective：To investigate the correlation between anti-ds-DNA antibody and complete blood count parameters in systemic lupus erythematosus（SLE）.Method：Sixty-two SLE patients and 50 healthy controls were selected.Anti-ds-DNA antibody and complete blood count parameters were measured.The correlation between anti-ds-DNA antibody and complete blood count parameters were analyzed.Result：Compared with the negative group,the low white blood cell count and classification count antibody of low titer anti-ds-DNA antibody positive group were lower.Compared with the low titer group,ratio of large platelet and platelet distribution width of high titer anti-ds-DNA antibody positive group increased significantly.The differences of coefficient of variation of red blood cell distribution width between anti-ds-DNA antibody negative and low titer positive group and low titer positive and high titer positive group were statistically significant.Conclusion：The changes of RDW-CV parameters were closely related to the change of condition in SLE.Complete blood count could be used as a simple and practical laboratory test index to reflect the change in patients with SLE.