新疆巴楚县维吾尔族妇女HPV感染、宫颈高级别病变及宫颈癌与微量元素、维生素的关系研究

Relationship between human papilloavirus infection,high-grade cervical lesions including cervical cancer and trace elements for Uyghur women in Bachu County,Xinj iang

目的探讨新疆巴楚县维吾尔族妇女 HPV感染、宫颈高级别病变及宫颈癌与血清中微量元素的关系，为宫颈癌的预防提供新的思路。方法以2014年3月1日-6月15日在巴楚县9个乡镇的宫颈癌筛查中所得的646例留取血液标本及2011年3月1日－2014年6月15日在新疆医科大学附属肿瘤医院妇科住院确诊的来自巴楚县的宫颈病变患者187例作为研究对象，检测血液中的微量元素硒（Se）、镍（Ni）、铁（Fe）、铜（Cu）、锌（Zn），血液微量元素 Se采用原子荧光光谱法（AFS，Atomic Fluorescence Spectrometry）进行检测，Ni、Fe、Cu、Zn采用电子耦合-等离子体原子发射光谱仪（ICP-MS）进行检测，使用 care HPV 方法检测 Human papilloma virus （HPV）感染情况。结果微量元素与 HPV感染及宫颈高级别病变及宫颈癌相关因素分析中，Ni≥0．1232 mg／kg、Se≥0．02 mg／kg是 HPV感染的保护因素；血清中 Fe≥6．9153 mmol／L是宫颈高级病变及宫颈癌的危险因素，而Ni≥0．0965 mg／kg、Se≥0．02 mg／kg则是宫颈高级病变及宫颈癌的保护因素。结论血清中 Ni和 Se水平在一定范围内对宫颈病变的发生及 HPV感染起保护作用，Fe在血液中的水平达到某种程度是宫颈高级别病变及宫颈癌的危险因素。因此，微量元素的检测在宫颈癌膳食为主的干预中起重要的作用。

Objective To study the relationship between HPV infection and high-grade cervical lesions in-cluding cervical cancer and trace elements in Uyghur women in Bachu of Xinjiang,which the diagnostic value of trace elements would be applied in predicting HPV infection and high cervical lesions in order to provide useful information for intervention of cervical cancer.Methods 187 objects with cervical disease from Bachu were enrolled in the department of gynecology in the Affiliated Tumor Hospital of Xinjiang Medical University.All participants underwent biopsy under colposcope for histopathologic examination. The concentration of trace elements of Ni,Cu,Zn,Se and Fe were determined by atomic absorption spec-trophotometry and inductively coupled plasma atomic emission spectroscopy, respectively.Using care HPV Human method to detect papilloma virus （HPV）.Results The concentration of Ni ≥0.123 2 mg/kg,Se≥ 0.02 mg/kg,who were protective factors.The concentration of Fe ≥ 6.915 3 mmol/L,who were risk factors for high cervical lesions including cervical cancer,and the concentration of Ni≥0.096 5 mg/kg and Se≥0.02 mg/kg,which were protective factors.Conclusion Serum levels of Ni,Fe and Se were correlated with the occurrence of cervical cancer and HPV infection and preventive measures should be taken to improve the status of trace elements.