血清白介素-13、白介素-4水平及吸入过敏原在新疆维吾尔族哮喘儿童相关研究

The correlation of serum interleukin-13,interleukin-4 and inhaled allergen in Xinjiang Uyghur children with asthma

目的探讨新疆维吾尔族哮喘儿童白介素-13(IL-13)、白介素-4(IL-4)水平及吸入过敏原检测的意义。方法采取双抗体夹心酶联免疫吸附法(ELISA)对新疆维吾尔族哮喘儿童及维吾尔族健康儿童进行血清IL-13、IL-4水平的检测,酶免法定性检测吸入过敏原,并进行比较。结果 (1)哮喘组IL-13水平[(8.12±4.78)ng/L]较对照组[(5.69±3.62)ng/L]高,差异有统计学意义(P<0.05),哮喘组IL-4水平[(10.64±27.90)ng/L]较对照组[(36.06±82.68)ng/L]低,但差异无统计学意义(P>0.05);(2)哮喘组IL-13、IL-4呈负相关(r=-1.116,P=0.514),对照组IL-13、IL-4呈正相关(r=0.121,P=0.575),但差异均无统学意义(P>0.05);(3)哮喘组儿童过敏原阳性率[76.5%(26例)]较对照组[50%(12例)]高,差异有统计学意义(P<0.05)。结论 IL-13、吸入过敏原在新疆维吾尔族哮喘儿童的发病过程中起着重要的作用。

Objective To discuss the significance of interleukin-13 （IL-13）and interleukin-4 （IL-4）levels and inhaled allergens of the Xinj iang Uyghur children with asthma.Methods Adopted double antibody sandwich enzyme-linked immunosorbent assay （ELISA）detection of serum IL-13,IL-4 levels,and enzyme immunoassay for qualitative detection of inhaled allergens between the asthmatic children and healthy chil-dren in Xinjiang Uygur Autonomous Region,and comparative analysis was conducted.Results （1）The level of IL-13 in asthma group [（8.12±4.78）ng/L]was higher than that in the control group [（5.69± 3.62）ng/L],which the difference was statistically significant （P〈0.05）,IL-4 level [（10.64±27.90）ng/L]in the asthma group was lower than that in the control group [（36.06±82.68）ng/L],but the difference was not statistically significant （P 〉0.05）;（2）IL-13 and IL-4 was negatively correlated in asthma group （r=-1.116,P =0.514）,while the control group was positive correlation （r=0.121,P =0.575）,but the difference was not significant （P 〉0.05）;（3）The positive rate of allergens in children with asthma was 76.5% （26 cases）,higher than the control group,which was 50% （12 cases）,and the difference was sta-tistically significant （P 〈0.05）.Conclusion IL-13 and inhaled allergens played an important role in the＆amp;nbsp;pathogenesis of asthma children in Xinjiang Uygur Autonomous Region.