IL-17F在口腔鳞状细胞癌患者血清中的表达及意义

Expression of Interleukin 17F in Serum of Oral Squamous Cell Carcinoma Patients and Its Clinic Significance

目的：探讨 IL-17F（interleukin 17F）在口腔鳞状细胞癌（OSCC）患者血清中的表达及意义。方法收集33例健康对照者、25例经病理证实为白斑的患者和80例 OSCC患者的血清，用 ELISA方法检测 IL-17F的表达水平，分析其与临床病理参数的关系。结果 OSCC患者血清 IL-17F水平为65.1±7.2 pg／ml，显著低于健康对照者（202.2±31.5 pg／ml）和白斑患者（168.2±17.4 pg／ml），差异均具有统计学意义（t＝6.16，6.22，P＜0.05），OSCC患者血清中IL-17F水平与TNM分期明显相关（P＜0.05）。受试者工作特征曲线（ROC曲线）显示血清中 IL-17 F能够很好地区分健康人和 OSCC患者（P＜0.05），其最佳临界值为37.8 pg／ml。结论 OSCC患者血清中 IL-17F的表达降低，提示其可能与肿瘤发生、发展相关。

Objective This study focus on the serum expression of IL-17F （interleukin 17F）and its’clinical diagnostic value for normal,leukoplakia patient and Oral Squamous Cell Carcinoma （OSCC）serum specimens.Methods The concentration of IL-17F in the serum was assessed by ELISA in healthy donors （n=33）,leukoplakia patients （n=25）and OSCC patients （n=80）.Results IL-17F concentration was lower in OSCC patients than in healthy donors and leukoplakia patients （65.1 pg/ml vs 202.2 pg/ml or 168.2 pg/ml,t=6.16,6.22,P〈0.05）.The expression of IL-17F was positively associated to TNM stage in OSCC （P〈0.05）.The receiver operating characteristic （ROC）curve suggests that IL-17F in serum was a good diagnostic marker to discriminate healthy people from leukoplakia patients,the cutoff values was 37.8 pg/ml.Conclu-sion The expression of IL-17F in serum correlated to OSCC progression and could be a potential diagnostic biomarker for oral disease.