EB病毒DNA载量与儿童肝肾损害的研究

Correlation Study between Children Hepatorenal Damage and EBV-DNA Load

目的：探讨 EB病毒DNA载量与肝、肾功能的关系。方法收集2016年4月～7月入院147例 EB病毒DNA阳性患儿，检测其 EB病毒DNA载量和生化指标；收集健康对照组80例。按照DNA载量的高低，分为低载量组80例，中载量组41例，高载量组26例，分析比较不同DNA载量与肝功能、年龄、性别的关系。结果 EB病毒 DNA低载量组、中载量组、高载量组肝损害率分别为17.50％，43.90％和61.54％；肾损害率分别为3.75％，12.2％和37.5％。DNA载量越高，发生肝、肾损害的概率越大，差异具有统计学意义（χ2＝20.58，8.38；P值均＜0.05）；低年龄组DNA载量（4.93±0.75）高于中年龄组（4.60±0.83）与大年龄组（4.63±0.84），差异具有统计学意义（Z＝－2.73，P＝0.006），中年龄组 DNA载量对数与高年龄组DNA载量对数间差异无统计学意义（Z＝－0.27，P＝0.788）。女患儿组 DNA载量对数（4.55±0.62）低于男患儿组DNA载量对数（4.93±0.86），差异具有统计学意义（Z＝－2.42，P＝0.015）。患儿组清蛋白低于对照组，差异具有统计学意义（Z＝－3.31，P＜0.005）。结论小儿感染 EB病毒，EB病毒 DNA载量越高，发生肝肾损害的可能性越大。

Objective To study the relationship between function of hepatorenal and DNA load of EBV.Methods 147 chil-dren whose EBV-DNA were positive were collected from April 2016 to July 2016,and their EBV-DNA load were tested.80 cases of normal children were collected as control group.ALL of them were divided into low load group （n=80）,middle load group （n=41）,high load group （n=26）by DNA load.Sex,age and condition of hepatorenal in each group was compared. Results Liver damage rate in low load group,middle load group and high load group was 17.50% ,43.90% and 61.54%respectively.Renal damage rate in low load group,middle load group and high load group was 3.75%,12.2% and 37.5%respectively.The higher DNA load was,the worse condition of hepatorenal got.The difference was statistically significant（P〈0.05）.The logarithm of DNA load in low age group （4.93±0.75）were significantly higher （Z=-2.73,P=0.006）than that in middle age group （4.60±0.83）as well as in high age group （4.63±0.84）.There was no significant difference be-tween the the logarithm of DNA load in middle age group and that in high age group （Z=-0.27,P=0.788）.The logarithm of DNA load in girl group （4.55±0.62）was significant lower（Z=-2.42,P=0.015）than boy group （4.93±0.86）.The levels of ALB in patient group were significant lower than control group（Z=-3.31,P〈0.005）.Conclusion With the lev-els of DNA load ascending,the possibility of occurrence live damage as well as renal damage get higher.