漫谈恶性肿瘤化疗的今昔与未来

Talk about Chemotherapy of Malignant Tumor:history and future

1943年氮芥首次用于治疗非霍奇金淋巴瘤患者,使患者病情获得缓解,为恶性肿瘤化疗药物发展拉开了历史性的序幕。随着医学发展模式的演进,化疗药物也在70年间突飞猛进。本文简要介绍了化疗药物中具有里程碑意义的氮芥、抗代谢类药物、顺铂、紫杉醇、乳腺癌内分泌治疗及分子靶向药物的早期发现过程,揭示了化疗药物的发展史完全遵循必然性与偶然性辩证统一的哲学规律,为今后恶性肿瘤化疗的研究与临床工作提供指导意义。

Nitrogen mustard was first used to treat a patient with non-Hodgkin＇s lymphoma in 1943,and the history of cancer chemotherapy drew back prologue just from here.In the wake of development in medicinal mode,anticancer drugs also had a breakneck development in the past seven-decade.This article provided brief information on early discovery process of milestone chemotherapy drug,including nitrogen mustard,antimetabolite,cisplatin,taxol,endocrine drugs for breast cancer and molecular targeted drug,revealed that development of cancer chemotherapy was the dialectical unity of necessity and contigency.This physiologic law could offer the guide for cancer chemotherapy research and clinic.