老年人良性阵发性位置性眩晕与血尿酸的关系

Relationship between benign paroxysmal positional vertigo and serum uric acid level in elderly patients

目的探讨血尿酸水平和老年人良性阵发性位置性眩晕（benign paroxysmal positional vertigo,BPPV）之间的相关性。方法收集2014年1月~2015年8月在我院住院≥60岁老年人102例BPPV患者作为BPPV组,并随机收集同期在我院≥60岁体检者85例作为对照组,分别测定血白蛋白、肌酐、尿酸、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、血压（收缩压、舒张压）,并收集记录二组病例心脑血管系统相关疾病及危险因素：高血压、糖尿病、冠心病、高血脂、脑梗死、脑出血、吸烟等病史。结果 BPPV组与对照组在性别、年龄、高血压史、糖尿病史、冠心病史、高血脂史、脑梗死史、脑出血史、吸烟史、甘油三酯、高密度脂蛋白、空腹血糖、肌酐、收缩压、舒张压等方面差异无统计学意义（P〉0.05）,但白蛋白、尿酸、总胆固醇、低密度脂蛋白在二组之间差异有统计学意义（P〈0.05）,BPPV组白蛋白、尿酸、总胆固醇、低密度脂蛋白显著高于对照组（P〈0.05）。采用多因素Logistic回归分析提示高尿酸、高低密度脂蛋白是老年人BPPV发病的危险因素。结论血清尿酸增高与老年人BPPV发病具有相关性,是老年人BPPV发病的危险因素。

OBJECTIVE To investigate the relationship between serum uric acid level and benign paroxysmal positional vertigo（BPPV） in elderly patients.METHODS We collected 102 cases of elderly patients over 60 years old with BPPV as a BPPV case group from January 2014 to August 2015 in the hospital,and randomly collected 85 cases of elderly people who got physical examination at the same period as the control group.Both were measured serum albumin,creatinine,uric acid,fasting blood glucose,total cholesterol,triglyceride,high density lipoprotein,low density lipoprotein,blood pressure（systolic blood pressure,diastolic blood pressure）,and collected the information of cardiovascular related diseases and the risk factors of the of two groups：hypertension,diabetes,coronary heart disease,hyperlipidemia,cerebral infarction,cerebral hemorrhage,smoking etc were collected.RESULTS There are no significant difference（P〉0.05）in gender,age,history of hypertension,diabetes,history of coronary heart disease,high blood lipids,history of cerebral infarction,history of cerebral hemorrhage,smoking history,triglyceride,high density lipoprotein,fasting blood glucose,creatinine,systolic blood pressure,diastolic blood pressure between BPPV group and control group,but there are significant difference（P〈0.05） in albumin,uric acid,total cholesterol,low density lipoprotein between the two groups.Logistic regression analysis suggests that higher uric acid level and higher low density lipoprotein level are risk factors for BPPV in elderly patients.CONCLUSION Serum uric acid are correlated with the incidence of BPPV in elderly patients,and it was a risk factor for BPPV in elderly patients.