评估术前系统免疫炎症指数与贲门癌患者预后的相关性

Evaluate the correlation between preoperative systemic immune-inflammation index and prognosis of patients after curative resection for cardia gastric cancer

目的探讨系统免疫炎症指数(SII)对贲门癌手术患者预后的相关性。方法回顾性分析2008年1月至2009年12月在苏州大学附属第三医院进行根治性贲门癌手术治疗的192例患者的临床病理资料,分析术前SII、CRP/Alb比值、临床病理特征与患者生存预后的相关性。结果单因素分析显示,术前SII>543.86和CRP/Alb>0.064是贲门癌患者总生存时间的危险因素。进一步的多因素分析表明:SII是贲门癌手术患者总生存时间的独立预后影响因素,风险比:1.584,95%置信区间:(1.072,2.342),P=0.021;CRP/Alb>0.064,亦应考虑有不良预后风险,风险比:1.316,95%置信区间:(0.909,1.906),P=0.146。结论术前SII对判断贲门癌患者的预后评估具有重要意义。

Objective To investigate the prognostic value of preoperative systemic immune-inflammation index（SII） in the patients with cardia gastric cancer after operation. Methods Clinical and pathological data of 192 patients who underwent potentially curative resection for cardia gastric cancer from January 2008 to December 2009 at the Third Affiliated Hospital of Soochow University were collected, and the correlation between preoperative SII, CRP/Alb ratios and clinicopathological features with the prognosis were analyzed. Results Univariate analysis showed that preoperative SII 〉543.86 and CRP/Alb 〉0.064 are statistically significant prognostic factors. On multivariate analysis, preoperative SII as a continuous variable was a highly significant independent prognostic factor of OS in patients with cardia gastric cancer（hazard ratio： 1.584, 95% CI： 1.072, 2.342, P = 0.021）, and CRP/Alb 〉0.064 should also be considered as the risk factor of poor prognosis（hazard ratio： 1.316, 95% CI： 0.909, 1.906, P = 0.146）. Conclusion Preoperative SII is highly valuable for predicting the prognosis of patients with resectable cardia gastric cancer.