莫沙比利对胃食管反流病患者血清Ghrelin水平的影响

THE EFFECTS OF MOSAPRIDE ON THE LEVELS OF SERUM GHRELIN IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE

目的探讨莫沙比利对胃食管反流病患者(Gastroesophageal Reflax Disease,GERD)血清Ghrelin水平的影响。方法选取29例健康体检者作为对照组;胃食管反流病患者58例作为实验组(GERD组),其中反流性食管炎(Refluxesophagitis,RE)患者30例(RE组),非糜烂性反流病(Non-erosive reflux disease,NERD)患者28例(NERD组)。采用双抗体夹心酶联免疫吸附法(Enzylne-Iabeled immunosorbent assay,ELISA)检测各组Ghrelin水平的差异。RE、NERD组患者分别服用莫沙必利(5mg,tid)治疗4周,分别观察治疗前后两组患者血清Ghrelin水平的变化。结果与对照组相比,GERD组、RE组、NERD组患者血清Ghrelin水平明显减低,差异有统计学意义(P<0.01)。RE、NERD组相比,差异无统计学意义(P>0.05)。莫沙必利治疗4周后,RE、NERD组患者血清Ghrelin水平较治疗前明显升高,差异有统计学意义(P<0.01)。结论血清Ghrelin水平的降低,可能导致胃排空延迟,参与GERD的发病机制;莫沙比利可提高GERD患者血清Ghrelin水平。

Objective To explore the effects of sosapride on the levels of serum Ghrelin in patients with gastroesophageal reflux disease （GERD） .Methods Twenty‐night healthy people were selected as the con‐trol group .Fifty‐eight patients with GERD were selected as the experiment group ,which were further di‐vided into the reflux‐esophagitis （RE） group of 30 cases and the non‐erosive reflux disease （NERD） group of 28 cases .The levels of serum ghrelin were analyzed by double antibody enzyme‐linked immunosorbent assays （ELISA） .Patients in the RE group and the NERD group were treated with 5mg of mosapride three time a day for 4weeks .The changes in serum levels of ghrelin in both groups were examined before and af‐ter the treatments by ELISA .Results The expression levels of ghrelin were significantly decreased in the experi‐ment groups compared with the control group （ P 〈0 .01） .However ,no significant differences of serum ghrelin were founded between the RE group and the NERD group （ P 〉0 .05） .After 4 weeks of treatment with mosa‐pride ,the serum levels of ghrelin were significantly increased in the RE group and the NERD group （ P〈0 .01） . Conclusion Decreased ghrelin levels may delay gastric emptying and participate in the pathogenesis of GERD . Mosapride may increase the levels of ghrelin in serum of pa‐tients with GERD .