乳腺癌改良根治术后复发相关因素的临床分析

Clinical analysis of factors associated with recurrence after modified radical mastectomy

目的分析乳腺癌改良根治术后局部胸壁及区域淋巴结复发的相关因素。方法乳腺癌改良根治术后复发患者54例,对其复发和预后相关因素进行Kaplan-Meier单因素和Cox回归多因素生存分析。结果年龄、分子分型、复发时间、术后放疗及新辅助化疗因素均与复发密切相关(P<0.05);年龄≤40岁、复发时间≤3年、非Luminal型、无术后放疗以及无新辅助化疗的患者5年生存率较低(P<0.05);年龄小、复发时间早、非Luminal型以及无术后放疗是影响乳腺癌预后相关的独立危险因素(P<0.05)。结论发病年龄小、复发时间早、非Luminal型以及无术后放疗是影响乳腺癌预后相关的独立危险因素。

Objective To analyze the factors associated with recurrence after modified radical mastectomy.Methods Cox multivariate analysis and Kaplan-Meier analysis for the recurrence and survival rate were performed.Results The age,molecular typing,recurrence time,postoperative radiotherapy and neoadjuvant chemotherapy were closely related to the recurrence of breast cancer after modified radical mastectomy（P〈0.05）.Kaplan-Meier survival analysis showed that the patients of aged ≤ 40 years,the recurrence time≤ 3 years,non-Luminal type,without postoperative radiotherapy and neoadjuvant chemotherapy were with a lower 5-year survival（P〈0.05）.The younger age,earlier recurrence,non-Luminal type and without postoperative radiotherapy were the independent risk factors for poor prognosis in the patients with breast cancer after modified radical mastectomy（P〈0.05）.Conclusion Young age,earlier recurrence,non-Luminal style and without postoperative radiotherapy are the independent risk factors for the prognosis of the patients with breast cancer after modified radical mastectomy.