慢性低钠血症与骨折、骨质疏松的相关性

Correlation between hyponatremia and fractures,osteoporosis

低钠血症是临床最常见的一种电解质紊乱,急性或重度低钠血症往往会出现明显症状被广泛关注和研究,但慢性、轻中度低钠血症或血钠偏低状态往往因其病因复杂、无明显临床症状或症状隐匿被临床忽视。近年来越来越多的研究指出慢性、轻中度低钠血症与骨折、骨质疏松的发生存在明显的相关性,对其可能的机制从多个角度进行了初步探索。尽管低钠血症与骨病的相关性研究已被关注,但对其认识尚不充分,本文通过对低钠血症与骨折、骨质疏松的相关性研究进展进行综述,旨在为骨折、骨质疏松的预防与诊治提供新的方向。

Hyponatremia is the most common electrolyte disorder in clinical practice. Acute or severe hyponatremia is widely concerned, but mild chronic hyp0natremia or low sodium state is often ignored because of its complex etiology, not obvious clinical symptoms or clinically occult. Now more and more studies revealed that mild chronic hyponatremia could induce fractures. The possible mechanism has been explored from different aspects. Although the correlation between hy- ponatremia and bone health has been concerned, it has not been comprehensive recognized. Here the correlation between hyponatremia and fractures or osteoporosis is reviewed, in order to provide a new direction for the diagnosis and treatment of osteoporosis.